Upregulation of group 1 CD1 antigen presenting molecules in guinea pigs with experimental autoimmune encephalomyelitis: An immunohistochemical study

Barbara Cipriani, Lanfen Chen, Kenji Hiromatsu, Heather Knowles, Cedric S. Raine, Luca Battistini, Steven A. Porcelli, Celia F. Brosnan

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In humans, group 1 CD1 glycoproteins present foreign and self lipid and glycolipid antigens to T-cells. Homologues of these molecules are not found in mice or rats but are present in guinea pigs (GPs). We examined CD1 and MHC class II expression in the central nervous system (CNS) of GPs sensitized for experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. In normal GPs and the uninflamed CNS, low-level MHC class II (MHC II) immunoreactivity occurred on vascular elements, meningeal macrophages and parenchymal microglial cells, whereas immunoreactivity for CD1 was absent. In the inflamed CNS, the majority of infiltrating cells were MHC II+ and microglia showed increased expression. CD1 immunoreactivity was detected on astrocytes and subsets of inflammatory cells including B cells and macrophages. Minimal CD1 and MHC II co-expression was noted on inflammatory cells or glia. We conclude that group 1 CD1 molecules are strongly upregulated in the inflamed CNS on subsets of cells distinct from the majority of MHC II bearing cells. The expression of CD1 proteins in such lesions broadens the potential repertoire of antigens recognized at these sites and highlights the value of the GP as a model for studies of the relevance of CD1 molecules in host defense and autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalBrain Pathology
Volume13
Issue number1
StatePublished - Jan 2003
Externally publishedYes

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CD1 Antigens
Autoimmune Experimental Encephalomyelitis
Guinea Pigs
Up-Regulation
Central Nervous System
Macrophages
Antigens
Glycolipids
Microglia
Neuroglia
Astrocytes
Autoimmune Diseases
Multiple Sclerosis
Blood Vessels
Glycoproteins
B-Lymphocytes
Animal Models
T-Lymphocytes
Lipids

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine

Cite this

Cipriani, B., Chen, L., Hiromatsu, K., Knowles, H., Raine, C. S., Battistini, L., ... Brosnan, C. F. (2003). Upregulation of group 1 CD1 antigen presenting molecules in guinea pigs with experimental autoimmune encephalomyelitis: An immunohistochemical study. Brain Pathology, 13(1), 1-9.

Upregulation of group 1 CD1 antigen presenting molecules in guinea pigs with experimental autoimmune encephalomyelitis : An immunohistochemical study. / Cipriani, Barbara; Chen, Lanfen; Hiromatsu, Kenji; Knowles, Heather; Raine, Cedric S.; Battistini, Luca; Porcelli, Steven A.; Brosnan, Celia F.

In: Brain Pathology, Vol. 13, No. 1, 01.2003, p. 1-9.

Research output: Contribution to journalArticle

Cipriani, B, Chen, L, Hiromatsu, K, Knowles, H, Raine, CS, Battistini, L, Porcelli, SA & Brosnan, CF 2003, 'Upregulation of group 1 CD1 antigen presenting molecules in guinea pigs with experimental autoimmune encephalomyelitis: An immunohistochemical study', Brain Pathology, vol. 13, no. 1, pp. 1-9.
Cipriani, Barbara ; Chen, Lanfen ; Hiromatsu, Kenji ; Knowles, Heather ; Raine, Cedric S. ; Battistini, Luca ; Porcelli, Steven A. ; Brosnan, Celia F. / Upregulation of group 1 CD1 antigen presenting molecules in guinea pigs with experimental autoimmune encephalomyelitis : An immunohistochemical study. In: Brain Pathology. 2003 ; Vol. 13, No. 1. pp. 1-9.
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