Upper airway motion analysis in obstructive sleep apnea syndrome (OSAS) via dynamic MRI

You Hao, Jayaram K. Udupa, Yubing Tong, Drew A. Torigian, Zihan Huang, Rachel M. Kogan, Lipeng Xie, David Wootton, Kokren Choy, Sanghun Sin, Mark E. Wagshul, Raanan Arens

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Obstructive sleep apnea syndrome (OSAS) is one of the most common sleep disorders that endangers human health, which is associated with episodes of apnea or hypopnea during sleep. In children, OSAS is associated with cardiovascular morbidity, neurobehavioral deficits, and poor quality of life, which highlights the importance for early diagnosis and treatment. Recent studies using dynamic magnetic resonance imaging (dMRI) have shown that adults with OSAS exhibit airway narrowing in specific regions that display increased variability in diameter during sleep as compared with controls. In this paper, we propose a novel method to compare OSAS patients with control subjects during awake and asleep states to assess the regional dynamic changes that occur in specific locations of the upper airway. Firstly, we segment the 3D upper airway with a previously developed fully automatic method. Then, different types of breathing cycles are selected by experts based on polysomnography. For each cycle, we calculate the distance of each point on the surface of the upper airway from end-expiration (EE) to end-inspiration (EI), which is then utilized for subsequent motion analysis. The 3D upper airway is subsequently divided into 4 anatomical parts manually. Lastly, comparisons of the dynamic upper airway motion measurements from different cycle groups are performed between OSAS patients and control subjects. Comparisons of different types of cycles within the same anatomical part demonstrated significant differences between control subjects and OSAS patients in all anatomic parts with some exceptions. These novel observations may provide some insights into the pathophysiology of OSAS.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2022
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsBarjor S. Gimi, Andrzej Krol
PublisherSPIE
ISBN (Electronic)9781510649477
DOIs
StatePublished - 2022
EventMedical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging - Virtual, Online
Duration: Mar 21 2022Mar 27 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12036
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging
CityVirtual, Online
Period3/21/223/27/22

Keywords

  • dynamic magnetic resonance imaging (dMRI)
  • motion analysis
  • obstructive sleep apnea syndrome (OSAS)
  • upper airway

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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