Unveiling YKL-40, from serum marker to target therapy in glioblastoma

Fabio M. Iwamoto, Adília Hormigo

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Glioblastoma is the most common primary brain tumor in the adult and carries a poor prognosis with a median survival of only 14 months. Patients with glioblastoma are followed with MRI scans, but this technique has several limitations including low specificity to differentiate between tumor and treatment effect. Development of serum markers could significantly improve the care of glioblastoma patients. We review the current concept of developing YKL-40 as one of the most promising serum markers for glioblastoma, the recent advances on understanding the role of YKL-40 in gliomagenesis, and the promising evidence emerging from preclinical models on using this protein as a target for anti-glioma therapy.

Original languageEnglish (US)
Article numberArticle 90
JournalFrontiers in Oncology
Volume4 APR
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Glioblastoma
  • Prognosis
  • Serum marker
  • Targeted therapy
  • YKL-40

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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