Unusual structural characteristics of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA

S. Khrapunov; H. Cheng; S. Hegde; J. Blanchard; M. Brenowitz

doi:10.1155/2010/259258

Unusual structural characteristics of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA

S. Khrapunov, H. Cheng, S. Hegde, J. Blanchard, M. Brenowitz

Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The solution structure and refolding of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA was explored by fluorescence and circular dichroism spectroscopy. Our results show that MfpA exists in two stable structural forms which exclusively favor dimer or oligomer formation. The structural malleability of MfpA may provide a novel target for drug discovery.

Original language	English (US)
Pages (from-to)	339-341
Number of pages	3
Journal	Spectroscopy
Volume	24
Issue number	3-4
DOIs	https://doi.org/10.1155/2010/259258
State	Published - 2010

Keywords

Protein structure
drug resistance
protein stability

ASJC Scopus subject areas

Spectroscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1155/2010/259258

Cite this

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abstract = "The solution structure and refolding of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA was explored by fluorescence and circular dichroism spectroscopy. Our results show that MfpA exists in two stable structural forms which exclusively favor dimer or oligomer formation. The structural malleability of MfpA may provide a novel target for drug discovery.",

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AU - Hegde, S.

AU - Blanchard, J.

AU - Brenowitz, M.

PY - 2010

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AB - The solution structure and refolding of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA was explored by fluorescence and circular dichroism spectroscopy. Our results show that MfpA exists in two stable structural forms which exclusively favor dimer or oligomer formation. The structural malleability of MfpA may provide a novel target for drug discovery.

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KW - drug resistance

KW - protein stability

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Unusual structural characteristics of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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