Untangling the Manganese-α-Synuclein Web

Tanara Vieira Peres, Nancy L. Parmalee, Ebany J. Martinez-Finley, Michael Aschner

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Neurodegenerative diseases affect a significant portion of the aging population. Several lines of evidence suggest a positive association between environmental exposures, which are common and cumulative in a lifetime, and development of neurodegenerative diseases. Environmental or occupational exposure to manganese (Mn) has been implicated in neurodegeneration due to its ability to induce mitochondrial dysfunction, oxidative stress, and a-synuclein (α-Syn) aggregation. The role of the α-Syn protein vis-a-vis Mn is controversial, as it seemingly plays a duplicitous role in neuroprotection and neurodegeneration. α-Syn has low affinity for Mn, however an indirect interaction cannot be ruled out. In this review we will examine the current knowledge surrounding the interaction of α-Syn and Mn in neurodegenerative process.

Original languageEnglish (US)
Article number364
JournalFrontiers in Neuroscience
Issue numberAUG
StatePublished - Aug 4 2016


  • Alpha-synuclien
  • Manganese
  • Neurotoxicity
  • Parkinson disease
  • Protein aggregation

ASJC Scopus subject areas

  • Neuroscience(all)


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