Abstract
Neurodegenerative diseases affect a significant portion of the aging population. Several lines of evidence suggest a positive association between environmental exposures, which are common and cumulative in a lifetime, and development of neurodegenerative diseases. Environmental or occupational exposure to manganese (Mn) has been implicated in neurodegeneration due to its ability to induce mitochondrial dysfunction, oxidative stress, and a-synuclein (α-Syn) aggregation. The role of the α-Syn protein vis-a-vis Mn is controversial, as it seemingly plays a duplicitous role in neuroprotection and neurodegeneration. α-Syn has low affinity for Mn, however an indirect interaction cannot be ruled out. In this review we will examine the current knowledge surrounding the interaction of α-Syn and Mn in neurodegenerative process.
Original language | English (US) |
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Article number | 364 |
Journal | Frontiers in Neuroscience |
Volume | 10 |
Issue number | AUG |
DOIs | |
State | Published - Aug 4 2016 |
Keywords
- Alpha-synuclien
- Manganese
- Neurotoxicity
- Parkinson disease
- Protein aggregation
ASJC Scopus subject areas
- General Neuroscience