Untangling the Manganese-α-Synuclein Web

Tanara Vieira Peres, Nancy L. Parmalee, Ebany J. Martinez-Finley, Michael Aschner

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Neurodegenerative diseases affect a significant portion of the aging population. Several lines of evidence suggest a positive association between environmental exposures, which are common and cumulative in a lifetime, and development of neurodegenerative diseases. Environmental or occupational exposure to manganese (Mn) has been implicated in neurodegeneration due to its ability to induce mitochondrial dysfunction, oxidative stress, and a-synuclein (α-Syn) aggregation. The role of the α-Syn protein vis-a-vis Mn is controversial, as it seemingly plays a duplicitous role in neuroprotection and neurodegeneration. α-Syn has low affinity for Mn, however an indirect interaction cannot be ruled out. In this review we will examine the current knowledge surrounding the interaction of α-Syn and Mn in neurodegenerative process.

Original languageEnglish (US)
Article number364
JournalFrontiers in Neuroscience
Volume10
Issue numberAUG
DOIs
StatePublished - Aug 4 2016

Fingerprint

Synucleins
Manganese
Environmental Exposure
Neurodegenerative Diseases
Occupational Exposure
Oxidative Stress
Population
Proteins

Keywords

  • Alpha-synuclien
  • Manganese
  • Neurotoxicity
  • Parkinson disease
  • Protein aggregation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Peres, T. V., Parmalee, N. L., Martinez-Finley, E. J., & Aschner, M. (2016). Untangling the Manganese-α-Synuclein Web. Frontiers in Neuroscience, 10(AUG), [364]. https://doi.org/10.3389/fnins.2016.00364

Untangling the Manganese-α-Synuclein Web. / Peres, Tanara Vieira; Parmalee, Nancy L.; Martinez-Finley, Ebany J.; Aschner, Michael.

In: Frontiers in Neuroscience, Vol. 10, No. AUG, 364, 04.08.2016.

Research output: Contribution to journalReview article

Peres, TV, Parmalee, NL, Martinez-Finley, EJ & Aschner, M 2016, 'Untangling the Manganese-α-Synuclein Web', Frontiers in Neuroscience, vol. 10, no. AUG, 364. https://doi.org/10.3389/fnins.2016.00364
Peres, Tanara Vieira ; Parmalee, Nancy L. ; Martinez-Finley, Ebany J. ; Aschner, Michael. / Untangling the Manganese-α-Synuclein Web. In: Frontiers in Neuroscience. 2016 ; Vol. 10, No. AUG.
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