Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2

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76 Scopus citations

Abstract

The present nomenclature of the splice variants of the lysosome-associated membrane protein type 2 (LAMP-2) is confusing. The LAMP-2a isoform is uniformly named in human, chicken, and mouse, but the LAMP-2b and LAMP-2c isoforms are switched in human as compared with mouse and chicken. We propose to change the nomenclature of the chicken and mouse b and c isoforms to agree with that currently used for the human isoforms. To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C.

Original languageEnglish (US)
Pages (from-to)1058-1061
Number of pages4
JournalTraffic
Volume6
Issue number11
DOIs
StatePublished - Nov 1 2005

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Keywords

  • Alternative splicing
  • Isoforms
  • LAMP-1
  • LAMP-2
  • LAMP1
  • LAMP2
  • Lysosome

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2. / Eskelinen, Eeva Liisa; Cuervo, Ana Maria; Taylor, Matthew R.G.; Nishino, Ichizo; Blum, Janice S.; Dice, J. Fred; Sandoval, Ignacio V.; Lippincott-Schwartz, Jennifer; August, J. Thomas; Saftig, Paul.

In: Traffic, Vol. 6, No. 11, 01.11.2005, p. 1058-1061.

Research output: Contribution to journalArticle