Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2

Eeva Liisa Eskelinen, Ana Maria Cuervo, Matthew R.G. Taylor, Ichizo Nishino, Janice S. Blum, J. Fred Dice, Ignacio V. Sandoval, Jennifer Lippincott-Schwartz, J. Thomas August, Paul Saftig

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

The present nomenclature of the splice variants of the lysosome-associated membrane protein type 2 (LAMP-2) is confusing. The LAMP-2a isoform is uniformly named in human, chicken, and mouse, but the LAMP-2b and LAMP-2c isoforms are switched in human as compared with mouse and chicken. We propose to change the nomenclature of the chicken and mouse b and c isoforms to agree with that currently used for the human isoforms. To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C.

Original languageEnglish (US)
Pages (from-to)1058-1061
Number of pages4
JournalTraffic
Volume6
Issue number11
DOIs
StatePublished - Nov 1 2005

Keywords

  • Alternative splicing
  • Isoforms
  • LAMP-1
  • LAMP-2
  • LAMP1
  • LAMP2
  • Lysosome

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Eskelinen, E. L., Cuervo, A. M., Taylor, M. R. G., Nishino, I., Blum, J. S., Dice, J. F., Sandoval, I. V., Lippincott-Schwartz, J., August, J. T., & Saftig, P. (2005). Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2. Traffic, 6(11), 1058-1061. https://doi.org/10.1111/j.1600-0854.2005.00337.x