TY - JOUR
T1 - Undiagnosed HIV and HCV infection in a New York City emergency department, 2015
AU - Torian, Lucia V.
AU - Felsen, Uriel R.
AU - Xia, Qiang
AU - Laraque, Fabienne
AU - Rude, Eric J.
AU - Rose, Herbert
AU - Cole, Adam
AU - Bocour, Angelica
AU - Williams, Gary J.
AU - Bridgforth, Robert F.
AU - Forgione, Lisa A.
AU - Doo, Howard
AU - Braunstein, Sarah L.
AU - Daskalakis, Demetre C.
AU - Zingman, Barry S.
N1 - Publisher Copyright:
© 2018 American Public Health Association Inc. All Rights Reserved.
PY - 2018/5
Y1 - 2018/5
N2 - Objectives. To measure undiagnosed HIV and HCV in a New York City emergency department (ED). Methods. We conducted a blinded cross-sectional serosurvey with remnant serum from specimens originally drawn for clinical indications in the ED. Serum was dedupli-cated and matched to (1) the hospital’s electronic medical record and (2) the New York City HIV and HCV surveillance registries for evidence of previous diagnosis before being deidentified and tested for HIV and HCV. Results. The overall prevalence of HIV was 5.0% (250/4990; 95% confidence interval [CI] = 4.4%, 5.7%); the prevalence of undiagnosed HIV was 0.2% (12/4990; 95% CI = 0.1%, 0.4%); and the proportion of undiagnosed HIV was 4.8% (12/250; 95% CI = 2.5%, 8.2%). The overall prevalence of HCV (HCV RNA ‡ 15 international units per milliliter) was 3.9% (196/4989; 95% CI = 2.8%, 5.1%); the prevalence of undiagnosed HCV was 0.8% (38/ 4989; 95% CI = 0.3%, 1.3%); and the proportion of undiagnosed HCV was 19.2% (38/196; 95% CI = 11.4%, 27.0%). Conclusions. Undiagnosed HCV was more prevalent than undiagnosed HIV in this population, suggesting that aggressive testing initiatives similar to those directed toward HIV should be mounted to improve HCV diagnosis.
AB - Objectives. To measure undiagnosed HIV and HCV in a New York City emergency department (ED). Methods. We conducted a blinded cross-sectional serosurvey with remnant serum from specimens originally drawn for clinical indications in the ED. Serum was dedupli-cated and matched to (1) the hospital’s electronic medical record and (2) the New York City HIV and HCV surveillance registries for evidence of previous diagnosis before being deidentified and tested for HIV and HCV. Results. The overall prevalence of HIV was 5.0% (250/4990; 95% confidence interval [CI] = 4.4%, 5.7%); the prevalence of undiagnosed HIV was 0.2% (12/4990; 95% CI = 0.1%, 0.4%); and the proportion of undiagnosed HIV was 4.8% (12/250; 95% CI = 2.5%, 8.2%). The overall prevalence of HCV (HCV RNA ‡ 15 international units per milliliter) was 3.9% (196/4989; 95% CI = 2.8%, 5.1%); the prevalence of undiagnosed HCV was 0.8% (38/ 4989; 95% CI = 0.3%, 1.3%); and the proportion of undiagnosed HCV was 19.2% (38/196; 95% CI = 11.4%, 27.0%). Conclusions. Undiagnosed HCV was more prevalent than undiagnosed HIV in this population, suggesting that aggressive testing initiatives similar to those directed toward HIV should be mounted to improve HCV diagnosis.
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U2 - 10.2105/AJPH.2018.304321
DO - 10.2105/AJPH.2018.304321
M3 - Comment/debate
C2 - 29565667
AN - SCOPUS:85045011733
SN - 0090-0036
VL - 108
SP - 652
EP - 658
JO - American journal of public health
JF - American journal of public health
IS - 5
ER -
