Understanding the short- and long-term respiratory outcomes of prematurity and bronchopulmonary dysplasia

Jessica Y. Islam, Roberta L. Keller, Judy L. Aschner, Tina V. Hartert, Paul E. Moore

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease associated with premature birth that primarily affects infants born at less than 28 weeks' gestational age. BPD is the most common serious complication experienced by premature infants, with more than 8,000 newly diagnosed infants annually in the United States alone. In light of the increasing numbers of preterm survivors with BPD, improving the current state of knowledge of long-term respiratory morbidity for infants with BPD is a priority. We undertook a comprehensive review of the published literature to analyze and consolidate current knowledge of the effects of BPD that are recognized at specific stages of life, including infancy, childhood, and adulthood. In this review, we discuss both the short-term and long-term respiratory outcomes of individuals diagnosed as infants with the disease and highlight the gaps in knowledge needed to improve early and lifelong management of these patients.

Original languageEnglish (US)
Pages (from-to)134-156
Number of pages23
JournalAmerican journal of respiratory and critical care medicine
Volume192
Issue number2
DOIs
StatePublished - Jul 15 2015

Keywords

  • Bronchopulmonary dysplasia
  • Preterm birth
  • Respiratory outcomes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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