Understanding the Link Between Gut Microbiome and Urinary Stone Disease

Justin A. Lee, Joshua M. Stern

Research output: Contribution to journalReview article

Abstract

Purpose of Review: With recent advances in sequencing technologies and increasing research into the gut microbiome (GMB), studies have revealed associations between the GMB and urinary stone disease (USD). We sought to determine whether the evidence pointed towards a few specific gut bacteria or the broader GMB network is seemingly responsible for this relationship. Recent Findings: Initially, Oxalobacter formigenes (OF) was pursued as the main link between GMB and USD given its ability to degrade oxalate in the gut. However, the latest studies consistently suggest that the entire GMB is much more likely to be involved in handling oxalate absorption and other risk factors for urinary stone formation, rather than just a few microbiota. Summary: The GMB has complex networks that are likely involved in the pathophysiology of USD, although the causal mechanisms remain unclear. With increasing interest and research, potential modalities that act on the GMB may help to prevent incidence of USD.

Original languageEnglish (US)
Article number19
JournalCurrent Urology Reports
Volume20
Issue number5
DOIs
StatePublished - May 1 2019

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Urinary Calculi
Oxalates
Oxalobacter formigenes
Microbiota
Gastrointestinal Microbiome
Research
Technology
Bacteria
Incidence

Keywords

  • Endourology
  • Gut microbiome
  • Urinary stone diseaseOxalobacter formigenes

ASJC Scopus subject areas

  • Urology

Cite this

Understanding the Link Between Gut Microbiome and Urinary Stone Disease. / Lee, Justin A.; Stern, Joshua M.

In: Current Urology Reports, Vol. 20, No. 5, 19, 01.05.2019.

Research output: Contribution to journalReview article

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