Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-Π2 and NF-ΰB

Sudarshana Purkayastha, Guo Zhang, Dongsheng Cai

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

Obesity-related hypertension has become an epidemic health problem and a major risk factor for the development of cardiovascular disease (CVD). Recent research on the pathophysiology of obesity has implicated a role for the hypothalamus in the pathogenesis of this condition. However, it remains unknown whether the often-seen coupling of hypertension with obesity can also be explained by hypothalamic dysfunction, despite the emerging appreciation that many forms of hypertension are neurogenic in origin. Our studies here revealed that acute activation of the proinflammatory protein nuclear factor °B (NF-κ °B) and its upstream activator I°B kinase-2 (IKK-2, encoded by Ikbkb) in the mediobasal hypothalamus rapidly elevated blood pressure in mice independently of obesity. This form of hypothalamic inflammation-induced hypertension involved the sympathetic upregulation of hemodynamics and was reversed by sympathetic suppression. Loss-of-function studies further showed that NF-κ °B inhibition in the mediobasal hypothalamus counteracted obesity-related hypertension in a manner that was dissociable from changes in body weight. In addition, we found that pro-opiomelanocortin (POMC) neurons were crucial for the hypertensive effects of the activation of hypothalamic IKK-2 and NF-κ °B, which underlie obesity-related hypertension. In conclusion, obesity-associated activation of IKK-2 and NF-κ °B in the mediobasal hypothalamus-particularly in the hypothalamic POMC neurons-is a primary pathogenic link between obesity and hypertension. Breaking this pathogenic link may represent an avenue for controlling obesity-related hypertension and CVD without requiring obesity control.

Original languageEnglish (US)
Pages (from-to)883-887
Number of pages5
JournalNature Medicine
Volume17
Issue number7
DOIs
StatePublished - Jul 2011

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Pro-Opiomelanocortin
Obesity
Chemical activation
Hypertension
Neurons
I-kappa B Kinase
Blood pressure
Hypothalamus
Hemodynamics
Medical problems
Nuclear Proteins
Cardiovascular Diseases
Body Weight Changes
Up-Regulation
Blood Pressure
Inflammation
Health
Research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-Π2 and NF-ΰB. / Purkayastha, Sudarshana; Zhang, Guo; Cai, Dongsheng.

In: Nature Medicine, Vol. 17, No. 7, 07.2011, p. 883-887.

Research output: Contribution to journalArticle

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