Unconventional NMDA receptor signaling

Kim Dore, Ivar S. Stein, Jennifer A. Brock, Pablo E. Castillo, Karen Zito, P. Jesper Sjöström

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In the classical view, NMDA receptors (NMDARs) are stably expressed at the postsynaptic membrane, where they act via Ca2+ to signal coincidence detection in Hebbian plasticity. More recently, it has been established that NMDAR-mediated transmission can be dynamically regulated by neural activity. In addition, NMDARs have been found presynaptically, where they cannot act as conventional coincidence detectors. Unexpectedly, NMDARs have also been shown to signal metabotropically, without the need for Ca2+. This review highlights novel findings concerning these unconventional modes of NMDAR action.

Original languageEnglish (US)
Pages (from-to)10800-10807
Number of pages8
JournalJournal of Neuroscience
Volume37
Issue number45
DOIs
StatePublished - Nov 8 2017

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Keywords

  • Alzheimer’s disease
  • LTD
  • LTP
  • Metabotropic NMDA receptor
  • Presynaptic NMDA receptor
  • Short-term plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dore, K., Stein, I. S., Brock, J. A., Castillo, P. E., Zito, K., & Sjöström, P. J. (2017). Unconventional NMDA receptor signaling. Journal of Neuroscience, 37(45), 10800-10807. https://doi.org/10.1523/JNEUROSCI.1825-17.2017

Unconventional NMDA receptor signaling. / Dore, Kim; Stein, Ivar S.; Brock, Jennifer A.; Castillo, Pablo E.; Zito, Karen; Sjöström, P. Jesper.

In: Journal of Neuroscience, Vol. 37, No. 45, 08.11.2017, p. 10800-10807.

Research output: Contribution to journalArticle

Dore, K, Stein, IS, Brock, JA, Castillo, PE, Zito, K & Sjöström, PJ 2017, 'Unconventional NMDA receptor signaling', Journal of Neuroscience, vol. 37, no. 45, pp. 10800-10807. https://doi.org/10.1523/JNEUROSCI.1825-17.2017
Dore K, Stein IS, Brock JA, Castillo PE, Zito K, Sjöström PJ. Unconventional NMDA receptor signaling. Journal of Neuroscience. 2017 Nov 8;37(45):10800-10807. https://doi.org/10.1523/JNEUROSCI.1825-17.2017
Dore, Kim ; Stein, Ivar S. ; Brock, Jennifer A. ; Castillo, Pablo E. ; Zito, Karen ; Sjöström, P. Jesper. / Unconventional NMDA receptor signaling. In: Journal of Neuroscience. 2017 ; Vol. 37, No. 45. pp. 10800-10807.
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