Abstract
In the classical view, NMDA receptors (NMDARs) are stably expressed at the postsynaptic membrane, where they act via Ca2+ to signal coincidence detection in Hebbian plasticity. More recently, it has been established that NMDAR-mediated transmission can be dynamically regulated by neural activity. In addition, NMDARs have been found presynaptically, where they cannot act as conventional coincidence detectors. Unexpectedly, NMDARs have also been shown to signal metabotropically, without the need for Ca2+. This review highlights novel findings concerning these unconventional modes of NMDAR action.
Original language | English (US) |
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Pages (from-to) | 10800-10807 |
Number of pages | 8 |
Journal | Journal of Neuroscience |
Volume | 37 |
Issue number | 45 |
DOIs | |
State | Published - Nov 8 2017 |
Keywords
- Alzheimer’s disease
- LTD
- LTP
- Metabotropic NMDA receptor
- Presynaptic NMDA receptor
- Short-term plasticity
ASJC Scopus subject areas
- General Neuroscience