@article{a5cf862922c240f689a09d01a1a3f8c5,
title = "Unconventional NMDA receptor signaling",
abstract = "In the classical view, NMDA receptors (NMDARs) are stably expressed at the postsynaptic membrane, where they act via Ca2+ to signal coincidence detection in Hebbian plasticity. More recently, it has been established that NMDAR-mediated transmission can be dynamically regulated by neural activity. In addition, NMDARs have been found presynaptically, where they cannot act as conventional coincidence detectors. Unexpectedly, NMDARs have also been shown to signal metabotropically, without the need for Ca2+. This review highlights novel findings concerning these unconventional modes of NMDAR action.",
keywords = "Alzheimer{\textquoteright}s disease, LTD, LTP, Metabotropic NMDA receptor, Presynaptic NMDA receptor, Short-term plasticity",
author = "Kim Dore and Stein, {Ivar S.} and Brock, {Jennifer A.} and Castillo, {Pablo E.} and Karen Zito and Sj{\"o}str{\"o}m, {P. Jesper}",
note = "Funding Information: This work was supported by Canadian Institutes of Health Research OG 126137 to P.J.S., Canadian Institutes of Health Research NIA 288936 to P.J.S., Natural Sciences and Engineering Research Council DG 418546-2 to P.J.S., Natural Sciences and Engineering Research Council DG 2017-04730 to P.J.S., Natural Sciences and Engineering Research Council DAS 2017-507818 to P.J.S., National Institutes of Health R01 DA017392 and MH081935 to P.E.C., National Institutes of Health AG032132 to K.D. and Roberto Malinow, Shiley-Marcos Endowment to Roberto Malinow, National Institutes of Health R01 NS062736 to K.Z., and Whitehall Foundation Grant 2014-05-99 to K.Z. We thank Roberto Malinow, Junmi M. Saikia, Alanna Watt, and Christina Chou for suggestions, help, and useful discussions. The authors declare no competing financial interests. Publisher Copyright: {\textcopyright} 2017 the authors.",
year = "2017",
month = nov,
day = "8",
doi = "10.1523/JNEUROSCI.1825-17.2017",
language = "English (US)",
volume = "37",
pages = "10800--10807",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "45",
}