TY - JOUR
T1 - Ultraviolet radiation and melanoma.
AU - Kanavy, Holly E.
AU - Gerstenblith, Meg R.
PY - 2011/12
Y1 - 2011/12
N2 - Melanoma is a particularly aggressive type of skin cancer, and its incidence has been increasing steadily since the 1970s. This article will review the extensive epidemiologic data demonstrating that ultraviolet radiation (UVR) exposure, from the sun or artificial tanning beds, is the most important environmental risk factor for melanoma; the multiple detrimental effects of UVR on human skin, including DNA damage through the formation of dimeric photoproducts, gene mutations, oxidative stress, inflammation, and immunosuppression, all of which contribute to melanomagenesis; and the evidence that protection from UVR exposure, whether by melanin or by sunscreen, reduces the risk of developing melanoma.
AB - Melanoma is a particularly aggressive type of skin cancer, and its incidence has been increasing steadily since the 1970s. This article will review the extensive epidemiologic data demonstrating that ultraviolet radiation (UVR) exposure, from the sun or artificial tanning beds, is the most important environmental risk factor for melanoma; the multiple detrimental effects of UVR on human skin, including DNA damage through the formation of dimeric photoproducts, gene mutations, oxidative stress, inflammation, and immunosuppression, all of which contribute to melanomagenesis; and the evidence that protection from UVR exposure, whether by melanin or by sunscreen, reduces the risk of developing melanoma.
UR - http://www.scopus.com/inward/record.url?scp=84858440852&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858440852&partnerID=8YFLogxK
U2 - 10.1016/j.sder.2011.08.003
DO - 10.1016/j.sder.2011.08.003
M3 - Review article
C2 - 22123420
AN - SCOPUS:84858440852
SN - 1085-5629
VL - 30
SP - 222
EP - 228
JO - Seminars in cutaneous medicine and surgery
JF - Seminars in cutaneous medicine and surgery
IS - 4
ER -