Ultrastructure of neurites and meganeurites of cortical pyramidal neurons in feline gangliosidosis as revealed by the combined Golgi-EM technique

S. U. Walkley, S. Wurzelmann, D. P. Purpura

Research output: Contribution to journalArticle

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Application of the Golgi-EM technique to the studt of altered cortical pyramidal neuron morphology in feline gangliosidosis has revealed the presence of aberrant synapses in relation to multiple neurites and secondary neurites of meganeurites. In addition fine neurites arising from the soma and meganeurite are found to project into and envelope elements of the sorrounding neuropil. These observations provide further evidence for a disturbance in neuronal surface membrane regulation in ganglioside storage disease.

Original languageEnglish (US)
Pages (from-to)393-398
Number of pages6
JournalBrain Research
Issue number2
Publication statusPublished - May 4 1981



  • aberrant neurite
  • animal model
  • combined Golgi-EM technique
  • gangliosidosis
  • pyramidal neuron

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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