Ultrastructure of neurites and meganeurites of cortical pyramidal neurons in feline gangliosidosis as revealed by the combined Golgi-EM technique

Steven U. Walkley, S. Wurzelmann, D. P. Purpura

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Application of the Golgi-EM technique to the studt of altered cortical pyramidal neuron morphology in feline gangliosidosis has revealed the presence of aberrant synapses in relation to multiple neurites and secondary neurites of meganeurites. In addition fine neurites arising from the soma and meganeurite are found to project into and envelope elements of the sorrounding neuropil. These observations provide further evidence for a disturbance in neuronal surface membrane regulation in ganglioside storage disease.

Original languageEnglish (US)
Pages (from-to)393-398
Number of pages6
JournalBrain Research
Volume211
Issue number2
DOIs
StatePublished - May 4 1981

Fingerprint

Gangliosidoses
Pyramidal Cells
Felidae
Neurites
Neuropil
Carisoprodol
Synapses
Membranes

Keywords

  • aberrant neurite
  • animal model
  • combined Golgi-EM technique
  • gangliosidosis
  • pyramidal neuron

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Ultrastructure of neurites and meganeurites of cortical pyramidal neurons in feline gangliosidosis as revealed by the combined Golgi-EM technique. / Walkley, Steven U.; Wurzelmann, S.; Purpura, D. P.

In: Brain Research, Vol. 211, No. 2, 04.05.1981, p. 393-398.

Research output: Contribution to journalArticle

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