Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease

Toshihiko Suenaga; Asao Hirano; Josefina F. Llena; Hanna Ksiezak‐Reding; Shu‐Hui ‐H Yen; Dennis W. Dickson

doi:10.1002/ana.410280210

Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease

Toshihiko Suenaga, Asao Hirano, Josefina F. Llena, Hanna Ksiezak‐Reding, Shu‐Hui ‐H Yen, Dennis W. Dickson

Pathology

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20 Scopus citations

Abstract

Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.

Original language	English (US)
Pages (from-to)	174-177
Number of pages	4
Journal	Annals of Neurology
Volume	28
Issue number	2
DOIs	https://doi.org/10.1002/ana.410280210
State	Published - Aug 1990

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease",

abstract = "Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.",

author = "Toshihiko Suenaga and Asao Hirano and Llena, {Josefina F.} and Hanna Ksiezak‐Reding and Yen, {Shu‐Hui ‐H} and Dickson, {Dennis W.}",

year = "1990",

month = aug,

doi = "10.1002/ana.410280210",

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AU - Suenaga, Toshihiko

AU - Hirano, Asao

AU - Llena, Josefina F.

AU - Ksiezak‐Reding, Hanna

AU - Yen, Shu‐Hui ‐H

AU - Dickson, Dennis W.

PY - 1990/8

Y1 - 1990/8

N2 - Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.

AB - Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.

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JO - Annals of Neurology

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Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease

Abstract

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