Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease

Toshihiko Suenaga, Asao Hirano, Josefina F. Llena, Hanna Ksiezak‐Reding, Shu‐Hui ‐H Yen, Dennis W. Dickson

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.

Original languageEnglish (US)
Pages (from-to)174-177
Number of pages4
JournalAnnals of Neurology
Volume28
Issue number2
DOIs
StatePublished - Aug 1990

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Suenaga, T., Hirano, A., Llena, J. F., Ksiezak‐Reding, H., Yen, SH. H., & Dickson, D. W. (1990). Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease. Annals of Neurology, 28(2), 174-177. https://doi.org/10.1002/ana.410280210