Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease

Toshihiko Suenaga, Asao Hirano, Josefina F. Llena, Hanna Ksiezak-Reding, Shu Hui Yen, Dennis W. Dickson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cerebellar kuru plaques in 2 cases of Creutzfeldt-Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin-positive, tau-negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt-Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.

Original languageEnglish (US)
Pages (from-to)174-177
Number of pages4
JournalAnnals of Neurology
Volume28
Issue number2
StatePublished - Aug 1990

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Kuru
Creutzfeldt-Jakob Syndrome
Ubiquitin
Alzheimer Disease
Amyloidogenic Proteins
Amyloid Plaques
Neurites

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Suenaga, T., Hirano, A., Llena, J. F., Ksiezak-Reding, H., Yen, S. H., & Dickson, D. W. (1990). Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease. Annals of Neurology, 28(2), 174-177.

Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease. / Suenaga, Toshihiko; Hirano, Asao; Llena, Josefina F.; Ksiezak-Reding, Hanna; Yen, Shu Hui; Dickson, Dennis W.

In: Annals of Neurology, Vol. 28, No. 2, 08.1990, p. 174-177.

Research output: Contribution to journalArticle

Suenaga, T, Hirano, A, Llena, JF, Ksiezak-Reding, H, Yen, SH & Dickson, DW 1990, 'Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease', Annals of Neurology, vol. 28, no. 2, pp. 174-177.
Suenaga T, Hirano A, Llena JF, Ksiezak-Reding H, Yen SH, Dickson DW. Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease. Annals of Neurology. 1990 Aug;28(2):174-177.
Suenaga, Toshihiko ; Hirano, Asao ; Llena, Josefina F. ; Ksiezak-Reding, Hanna ; Yen, Shu Hui ; Dickson, Dennis W. / Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease. In: Annals of Neurology. 1990 ; Vol. 28, No. 2. pp. 174-177.
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