U-Shaped Relation between Plasma Oxytocin Levels and Behavior in the Trust Game

Songfa Zhong, Mikhail Monakhov, Helen P. Mok, Terry Tong, Poh San Lai, Soo Hong Chew, Richard P. Ebstein

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Trust underpins much of social and economic exchanges across human societies. In experimental economics, the Trust Game has served as the workhorse for the study of trust in a controlled incentivized setting. Recent evidence using intranasal drug administration, aka 'sniffing', suggests that oxytocin (OT) can function as a social hormone facilitating trust and other affiliative behaviors. Here we hypothesized that baseline plasma OT is a biomarker that partially predicts the degree of trust and trustworthiness observed in the trust game. Using a large sample of 1,158 participants, we observed a significant U-shaped relationship between plasma OT with the level of trust, and marginally with the level of trustworthiness, especially among males. Specifically, subjects with more extreme levels of plasma OT were more likely to be trusting as well as trustworthy than those with moderate levels of plasma OT. Our results contribute to a deeper understanding of the biological basis of human trust and underscore the usefulness of peripheral plasma OT measures in characterizing human social behavior.

Original languageEnglish (US)
Article numbere51095
JournalPloS one
Volume7
Issue number12
DOIs
StatePublished - Dec 5 2012
Externally publishedYes

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oxytocin
Oxytocin
Plasmas
legal trusts
Economics
Intranasal Administration
Social Behavior
Biomarkers
human behavior
social behavior
biomarkers
hormones
Hormones
drugs
economics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Zhong, S., Monakhov, M., Mok, H. P., Tong, T., Lai, P. S., Chew, S. H., & Ebstein, R. P. (2012). U-Shaped Relation between Plasma Oxytocin Levels and Behavior in the Trust Game. PloS one, 7(12), [e51095]. https://doi.org/10.1371/journal.pone.0051095

U-Shaped Relation between Plasma Oxytocin Levels and Behavior in the Trust Game. / Zhong, Songfa; Monakhov, Mikhail; Mok, Helen P.; Tong, Terry; Lai, Poh San; Chew, Soo Hong; Ebstein, Richard P.

In: PloS one, Vol. 7, No. 12, e51095, 05.12.2012.

Research output: Contribution to journalArticle

Zhong, S, Monakhov, M, Mok, HP, Tong, T, Lai, PS, Chew, SH & Ebstein, RP 2012, 'U-Shaped Relation between Plasma Oxytocin Levels and Behavior in the Trust Game', PloS one, vol. 7, no. 12, e51095. https://doi.org/10.1371/journal.pone.0051095
Zhong, Songfa ; Monakhov, Mikhail ; Mok, Helen P. ; Tong, Terry ; Lai, Poh San ; Chew, Soo Hong ; Ebstein, Richard P. / U-Shaped Relation between Plasma Oxytocin Levels and Behavior in the Trust Game. In: PloS one. 2012 ; Vol. 7, No. 12.
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