Type-specific duration of human papillomavirus infection

Implications for human papillomavirus screening and vaccination

Helen Trottier, Salaheddin Mahmud, José Carlos M Prado, Joao S. Sobrinho, Maria C. Costa, Thomas E. Rohan, Luisa L. Villa, Eduardo L. Franco

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Background. Understanding the duration of human papillomavirus (HPV) infection may help find suitable end points for vaccine trials and testing intervals in screening studies. We studied genotype-specific infection duration among 2462 women enrolled in the Ludwig-McGill cohort study. Methods. Cervical specimens collected every 4-6 months were tested by a polymerase chain reaction protocol. Actuarial techniques were used to estimate the duration of HPV infection and to investigate the influence of age, number of sexual partners, and coinfection with multiple HPV types. Results. At enrollment, the prevalence of infection with high-risk HPV types was 10.6%, and the prevalence of infection with low-risk HPV types was 6.1%; incidence rates were 6.1 and 5.0 infections per 1000 women-months, respectively. Prevalent infections took longer to clear than incident infections (mean time to clearance, 18.6 months vs. 13.5 months). The mean duration of incident infection with high- and low-risk HPV varied according to the analytic approach used to measure this variable and showed considerable variation by HPV type (range, 5.1-15.4 months). Age and number of partners did not influence infection duration, whereas coinfection was associated with increased infection duration. The mean duration of HPV-16 monoinfection was 11.0 months, and the mean duration of HPV-16 coinfection was 15.4 months. Conclusion. There was considerable variation among HPV types with regard to the duration of infection. Coinfection with multiple types contributed to an increased infection duration.

Original languageEnglish (US)
Pages (from-to)1436-1447
Number of pages12
JournalJournal of Infectious Diseases
Volume197
Issue number10
DOIs
StatePublished - May 15 2008

Fingerprint

Papillomavirus Infections
Vaccination
Infection
Coinfection
Human papillomavirus 16
Sexual Partners
Cohort Studies
Vaccines
Genotype

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Type-specific duration of human papillomavirus infection : Implications for human papillomavirus screening and vaccination. / Trottier, Helen; Mahmud, Salaheddin; Prado, José Carlos M; Sobrinho, Joao S.; Costa, Maria C.; Rohan, Thomas E.; Villa, Luisa L.; Franco, Eduardo L.

In: Journal of Infectious Diseases, Vol. 197, No. 10, 15.05.2008, p. 1436-1447.

Research output: Contribution to journalArticle

Trottier, H, Mahmud, S, Prado, JCM, Sobrinho, JS, Costa, MC, Rohan, TE, Villa, LL & Franco, EL 2008, 'Type-specific duration of human papillomavirus infection: Implications for human papillomavirus screening and vaccination', Journal of Infectious Diseases, vol. 197, no. 10, pp. 1436-1447. https://doi.org/10.1086/587698
Trottier, Helen ; Mahmud, Salaheddin ; Prado, José Carlos M ; Sobrinho, Joao S. ; Costa, Maria C. ; Rohan, Thomas E. ; Villa, Luisa L. ; Franco, Eduardo L. / Type-specific duration of human papillomavirus infection : Implications for human papillomavirus screening and vaccination. In: Journal of Infectious Diseases. 2008 ; Vol. 197, No. 10. pp. 1436-1447.
@article{5c17dfdc58af4d56a6b57bf5c053ecae,
title = "Type-specific duration of human papillomavirus infection: Implications for human papillomavirus screening and vaccination",
abstract = "Background. Understanding the duration of human papillomavirus (HPV) infection may help find suitable end points for vaccine trials and testing intervals in screening studies. We studied genotype-specific infection duration among 2462 women enrolled in the Ludwig-McGill cohort study. Methods. Cervical specimens collected every 4-6 months were tested by a polymerase chain reaction protocol. Actuarial techniques were used to estimate the duration of HPV infection and to investigate the influence of age, number of sexual partners, and coinfection with multiple HPV types. Results. At enrollment, the prevalence of infection with high-risk HPV types was 10.6{\%}, and the prevalence of infection with low-risk HPV types was 6.1{\%}; incidence rates were 6.1 and 5.0 infections per 1000 women-months, respectively. Prevalent infections took longer to clear than incident infections (mean time to clearance, 18.6 months vs. 13.5 months). The mean duration of incident infection with high- and low-risk HPV varied according to the analytic approach used to measure this variable and showed considerable variation by HPV type (range, 5.1-15.4 months). Age and number of partners did not influence infection duration, whereas coinfection was associated with increased infection duration. The mean duration of HPV-16 monoinfection was 11.0 months, and the mean duration of HPV-16 coinfection was 15.4 months. Conclusion. There was considerable variation among HPV types with regard to the duration of infection. Coinfection with multiple types contributed to an increased infection duration.",
author = "Helen Trottier and Salaheddin Mahmud and Prado, {Jos{\'e} Carlos M} and Sobrinho, {Joao S.} and Costa, {Maria C.} and Rohan, {Thomas E.} and Villa, {Luisa L.} and Franco, {Eduardo L.}",
year = "2008",
month = "5",
day = "15",
doi = "10.1086/587698",
language = "English (US)",
volume = "197",
pages = "1436--1447",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Type-specific duration of human papillomavirus infection

T2 - Implications for human papillomavirus screening and vaccination

AU - Trottier, Helen

AU - Mahmud, Salaheddin

AU - Prado, José Carlos M

AU - Sobrinho, Joao S.

AU - Costa, Maria C.

AU - Rohan, Thomas E.

AU - Villa, Luisa L.

AU - Franco, Eduardo L.

PY - 2008/5/15

Y1 - 2008/5/15

N2 - Background. Understanding the duration of human papillomavirus (HPV) infection may help find suitable end points for vaccine trials and testing intervals in screening studies. We studied genotype-specific infection duration among 2462 women enrolled in the Ludwig-McGill cohort study. Methods. Cervical specimens collected every 4-6 months were tested by a polymerase chain reaction protocol. Actuarial techniques were used to estimate the duration of HPV infection and to investigate the influence of age, number of sexual partners, and coinfection with multiple HPV types. Results. At enrollment, the prevalence of infection with high-risk HPV types was 10.6%, and the prevalence of infection with low-risk HPV types was 6.1%; incidence rates were 6.1 and 5.0 infections per 1000 women-months, respectively. Prevalent infections took longer to clear than incident infections (mean time to clearance, 18.6 months vs. 13.5 months). The mean duration of incident infection with high- and low-risk HPV varied according to the analytic approach used to measure this variable and showed considerable variation by HPV type (range, 5.1-15.4 months). Age and number of partners did not influence infection duration, whereas coinfection was associated with increased infection duration. The mean duration of HPV-16 monoinfection was 11.0 months, and the mean duration of HPV-16 coinfection was 15.4 months. Conclusion. There was considerable variation among HPV types with regard to the duration of infection. Coinfection with multiple types contributed to an increased infection duration.

AB - Background. Understanding the duration of human papillomavirus (HPV) infection may help find suitable end points for vaccine trials and testing intervals in screening studies. We studied genotype-specific infection duration among 2462 women enrolled in the Ludwig-McGill cohort study. Methods. Cervical specimens collected every 4-6 months were tested by a polymerase chain reaction protocol. Actuarial techniques were used to estimate the duration of HPV infection and to investigate the influence of age, number of sexual partners, and coinfection with multiple HPV types. Results. At enrollment, the prevalence of infection with high-risk HPV types was 10.6%, and the prevalence of infection with low-risk HPV types was 6.1%; incidence rates were 6.1 and 5.0 infections per 1000 women-months, respectively. Prevalent infections took longer to clear than incident infections (mean time to clearance, 18.6 months vs. 13.5 months). The mean duration of incident infection with high- and low-risk HPV varied according to the analytic approach used to measure this variable and showed considerable variation by HPV type (range, 5.1-15.4 months). Age and number of partners did not influence infection duration, whereas coinfection was associated with increased infection duration. The mean duration of HPV-16 monoinfection was 11.0 months, and the mean duration of HPV-16 coinfection was 15.4 months. Conclusion. There was considerable variation among HPV types with regard to the duration of infection. Coinfection with multiple types contributed to an increased infection duration.

UR - http://www.scopus.com/inward/record.url?scp=43949129406&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43949129406&partnerID=8YFLogxK

U2 - 10.1086/587698

DO - 10.1086/587698

M3 - Article

VL - 197

SP - 1436

EP - 1447

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 10

ER -