TY - JOUR
T1 - Type-specific duration of human papillomavirus infection
T2 - Implications for human papillomavirus screening and vaccination
AU - Trottier, Helen
AU - Mahmud, Salaheddin
AU - Prado, José Carlos M.
AU - Sobrinho, Joao S.
AU - Costa, Maria C.
AU - Rohan, Thomas E.
AU - Villa, Luisa L.
AU - Franco, Eduardo L.
N1 - Funding Information:
Received 30 July 2007; accepted 10 December 2007; electronically published 15 April 2008. Potential conflicts of interest: none reported. Presented in part: 23rd International Papillomavirus Conference and Clinical Workshop, 1–7 September 2006, Prague, Czech Republic (abstract PS2–3). Financial support: Ludwig Institute for Cancer Research (intramural grant to L.L.V. and E.L.F.), US National Cancer Institute (grant CA70269 to E.L.F.), and Canadian Institutes of Health Research (Distinguished Scientist Award and grant MA13647 to E.L.F.). Reprints or correspondence: Prof. Eduardo L. Franco, Dept. of Oncology, McGill University, 546 Pine Ave. West, Montreal, QC, Canada H2W1S6 (eduardo.franco@mcgill.ca).
PY - 2008/5/15
Y1 - 2008/5/15
N2 - Background. Understanding the duration of human papillomavirus (HPV) infection may help find suitable end points for vaccine trials and testing intervals in screening studies. We studied genotype-specific infection duration among 2462 women enrolled in the Ludwig-McGill cohort study. Methods. Cervical specimens collected every 4-6 months were tested by a polymerase chain reaction protocol. Actuarial techniques were used to estimate the duration of HPV infection and to investigate the influence of age, number of sexual partners, and coinfection with multiple HPV types. Results. At enrollment, the prevalence of infection with high-risk HPV types was 10.6%, and the prevalence of infection with low-risk HPV types was 6.1%; incidence rates were 6.1 and 5.0 infections per 1000 women-months, respectively. Prevalent infections took longer to clear than incident infections (mean time to clearance, 18.6 months vs. 13.5 months). The mean duration of incident infection with high- and low-risk HPV varied according to the analytic approach used to measure this variable and showed considerable variation by HPV type (range, 5.1-15.4 months). Age and number of partners did not influence infection duration, whereas coinfection was associated with increased infection duration. The mean duration of HPV-16 monoinfection was 11.0 months, and the mean duration of HPV-16 coinfection was 15.4 months. Conclusion. There was considerable variation among HPV types with regard to the duration of infection. Coinfection with multiple types contributed to an increased infection duration.
AB - Background. Understanding the duration of human papillomavirus (HPV) infection may help find suitable end points for vaccine trials and testing intervals in screening studies. We studied genotype-specific infection duration among 2462 women enrolled in the Ludwig-McGill cohort study. Methods. Cervical specimens collected every 4-6 months were tested by a polymerase chain reaction protocol. Actuarial techniques were used to estimate the duration of HPV infection and to investigate the influence of age, number of sexual partners, and coinfection with multiple HPV types. Results. At enrollment, the prevalence of infection with high-risk HPV types was 10.6%, and the prevalence of infection with low-risk HPV types was 6.1%; incidence rates were 6.1 and 5.0 infections per 1000 women-months, respectively. Prevalent infections took longer to clear than incident infections (mean time to clearance, 18.6 months vs. 13.5 months). The mean duration of incident infection with high- and low-risk HPV varied according to the analytic approach used to measure this variable and showed considerable variation by HPV type (range, 5.1-15.4 months). Age and number of partners did not influence infection duration, whereas coinfection was associated with increased infection duration. The mean duration of HPV-16 monoinfection was 11.0 months, and the mean duration of HPV-16 coinfection was 15.4 months. Conclusion. There was considerable variation among HPV types with regard to the duration of infection. Coinfection with multiple types contributed to an increased infection duration.
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U2 - 10.1086/587698
DO - 10.1086/587698
M3 - Article
C2 - 18419547
AN - SCOPUS:43949129406
SN - 0022-1899
VL - 197
SP - 1436
EP - 1447
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 10
ER -