Type 2 Diabetes Mellitus and Pancreatic Cancer

John C. McAuliffe; John D. Christein

doi:10.1016/j.suc.2013.02.003

Type 2 Diabetes Mellitus and Pancreatic Cancer

John C. McAuliffe, John D. Christein

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Tumorigenesis of pancreatic cancer (PC) and the pathophysiology of type 2 diabetes mellitus (DM2) are emerging as intertwined pathways. As the operative morbidity and mortality of pancreatectomy has improved, incidence has increased and survival has remained mostly unchanged. The diagnosis of DM2 suggests pancreatic dysfunction and possible early carcinogenesis. DM2 is a significant comorbidity predicting worse outcomes in patients undergoing pancreatic resection as part of the treatment of PC. This article examines this phenomena and suggests possible approaches to screening and diagnosis.

Original language	English (US)
Pages (from-to)	619-627
Number of pages	9
Journal	Surgical Clinics of North America
Volume	93
Issue number	3
DOIs	https://doi.org/10.1016/j.suc.2013.02.003
State	Published - Jun 2013
Externally published	Yes

Keywords

Pancreatectomy
Pancreatic cancer
Type 2 diabetes mellitus

ASJC Scopus subject areas

Surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.suc.2013.02.003

Cite this

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title = "Type 2 Diabetes Mellitus and Pancreatic Cancer",

abstract = "Tumorigenesis of pancreatic cancer (PC) and the pathophysiology of type 2 diabetes mellitus (DM2) are emerging as intertwined pathways. As the operative morbidity and mortality of pancreatectomy has improved, incidence has increased and survival has remained mostly unchanged. The diagnosis of DM2 suggests pancreatic dysfunction and possible early carcinogenesis. DM2 is a significant comorbidity predicting worse outcomes in patients undergoing pancreatic resection as part of the treatment of PC. This article examines this phenomena and suggests possible approaches to screening and diagnosis.",

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T1 - Type 2 Diabetes Mellitus and Pancreatic Cancer

AU - McAuliffe, John C.

AU - Christein, John D.

PY - 2013/6

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N2 - Tumorigenesis of pancreatic cancer (PC) and the pathophysiology of type 2 diabetes mellitus (DM2) are emerging as intertwined pathways. As the operative morbidity and mortality of pancreatectomy has improved, incidence has increased and survival has remained mostly unchanged. The diagnosis of DM2 suggests pancreatic dysfunction and possible early carcinogenesis. DM2 is a significant comorbidity predicting worse outcomes in patients undergoing pancreatic resection as part of the treatment of PC. This article examines this phenomena and suggests possible approaches to screening and diagnosis.

AB - Tumorigenesis of pancreatic cancer (PC) and the pathophysiology of type 2 diabetes mellitus (DM2) are emerging as intertwined pathways. As the operative morbidity and mortality of pancreatectomy has improved, incidence has increased and survival has remained mostly unchanged. The diagnosis of DM2 suggests pancreatic dysfunction and possible early carcinogenesis. DM2 is a significant comorbidity predicting worse outcomes in patients undergoing pancreatic resection as part of the treatment of PC. This article examines this phenomena and suggests possible approaches to screening and diagnosis.

KW - Pancreatectomy

KW - Pancreatic cancer

KW - Type 2 diabetes mellitus

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AN - SCOPUS:84876991747

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JO - Surgical Clinics of North America

JF - Surgical Clinics of North America

IS - 3

ER -

Type 2 Diabetes Mellitus and Pancreatic Cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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