Type 1 HERV-K genome is spliced into subgenomic transcripts in the human breast tumor cell line T47D

Polly R. Etkind, Kathryn Lumb, Juan Du, Janis Racevskis

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Two types of HERV-K genomes exist which differ in the absence (type 1) or the presence (type 2) of a sequence of 292 nucleotides between the putative pol and any genes. Previously published results from teratocarcinoma cell studies had firmly concluded that the type 1 HERV-K genome was defective in splicing and that only the nondeleted type 2 HERV-K genome containing the 292-nucleotide sequence was capable of being spliced. We now show that in the T47D human breast tumor cell line it is the type 1 HERV-K genome, and not the type 2, which is spliced to subgenomic transcripts.

Original languageEnglish (US)
Pages (from-to)304-308
Number of pages5
JournalVirology
Volume234
Issue number2
DOIs
StatePublished - Aug 4 1997

Fingerprint

Endogenous Retroviruses
Tumor Cell Line
Genome
Breast Neoplasms
pol Genes
Teratocarcinoma

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Type 1 HERV-K genome is spliced into subgenomic transcripts in the human breast tumor cell line T47D. / Etkind, Polly R.; Lumb, Kathryn; Du, Juan; Racevskis, Janis.

In: Virology, Vol. 234, No. 2, 04.08.1997, p. 304-308.

Research output: Contribution to journalArticle

Etkind, Polly R. ; Lumb, Kathryn ; Du, Juan ; Racevskis, Janis. / Type 1 HERV-K genome is spliced into subgenomic transcripts in the human breast tumor cell line T47D. In: Virology. 1997 ; Vol. 234, No. 2. pp. 304-308.
@article{7dd18a2edc6143598eb4d0c86c6bfd78,
title = "Type 1 HERV-K genome is spliced into subgenomic transcripts in the human breast tumor cell line T47D",
abstract = "Two types of HERV-K genomes exist which differ in the absence (type 1) or the presence (type 2) of a sequence of 292 nucleotides between the putative pol and any genes. Previously published results from teratocarcinoma cell studies had firmly concluded that the type 1 HERV-K genome was defective in splicing and that only the nondeleted type 2 HERV-K genome containing the 292-nucleotide sequence was capable of being spliced. We now show that in the T47D human breast tumor cell line it is the type 1 HERV-K genome, and not the type 2, which is spliced to subgenomic transcripts.",
author = "Etkind, {Polly R.} and Kathryn Lumb and Juan Du and Janis Racevskis",
year = "1997",
month = "8",
day = "4",
doi = "10.1006/viro.1997.8670",
language = "English (US)",
volume = "234",
pages = "304--308",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Type 1 HERV-K genome is spliced into subgenomic transcripts in the human breast tumor cell line T47D

AU - Etkind, Polly R.

AU - Lumb, Kathryn

AU - Du, Juan

AU - Racevskis, Janis

PY - 1997/8/4

Y1 - 1997/8/4

N2 - Two types of HERV-K genomes exist which differ in the absence (type 1) or the presence (type 2) of a sequence of 292 nucleotides between the putative pol and any genes. Previously published results from teratocarcinoma cell studies had firmly concluded that the type 1 HERV-K genome was defective in splicing and that only the nondeleted type 2 HERV-K genome containing the 292-nucleotide sequence was capable of being spliced. We now show that in the T47D human breast tumor cell line it is the type 1 HERV-K genome, and not the type 2, which is spliced to subgenomic transcripts.

AB - Two types of HERV-K genomes exist which differ in the absence (type 1) or the presence (type 2) of a sequence of 292 nucleotides between the putative pol and any genes. Previously published results from teratocarcinoma cell studies had firmly concluded that the type 1 HERV-K genome was defective in splicing and that only the nondeleted type 2 HERV-K genome containing the 292-nucleotide sequence was capable of being spliced. We now show that in the T47D human breast tumor cell line it is the type 1 HERV-K genome, and not the type 2, which is spliced to subgenomic transcripts.

UR - http://www.scopus.com/inward/record.url?scp=0030840761&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030840761&partnerID=8YFLogxK

U2 - 10.1006/viro.1997.8670

DO - 10.1006/viro.1997.8670

M3 - Article

VL - 234

SP - 304

EP - 308

JO - Virology

JF - Virology

SN - 0042-6822

IS - 2

ER -