Two-year outcomes following unprotected left main stenting with first vs. new-generation drug-eluting stents: The FINE registry

Gill Louise Buchanan, Alaide Chieffo, Chiara Bernelli, Matteo Montorfano, Mauro Carlino, Azeem Latib, Filippo Figini, Francesco Giannini, Alessandro Durante, Alfonso Ielasi, Alfredo Castelli, Antonio Colombo

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Aims: To assess two-year outcomes following first vs. new-generation drug-eluting stent (DES) implantation in unprotected left main (ULMCA) percutaneous coronary intervention. Methods and results: All eligible patients from our two-centre registry treated with first and new-generation DES from October 2006 to November 2010 were analysed. The study objective was major adverse cardiac events (MACE), defined as all-cause mortality, target vessel revascularisation (TVR) and myocardial infarction (MI) at two years. In total, 186 patients were included: 93 (50.0%) treated with first vs. 93 (50.0%) with new-generation DES. No differences were observed in baseline clinical characteristics except for higher EuroSCORE with new-generation DES (3.6±2.5 vs. 4.6±2.7; p=0.007). No significant difference was observed in stenting techniques; two stents were used respectively in 53.8% vs. 44.1% (p=0.187). Notably, intravascular ultrasound guidance was more frequent with new-generation DES (46.2% vs. 61.3%; p=0.040). At 730.0 (interquartile range 365.5-1,224.5) days, there was a trend towards improved MACE with new-generation DES (31.2% vs. 19.6%; p=0.070) and a significant reduction in TVR (23.7% vs. 12.0%; p=0.038) and MI (4.3% vs. 0%; p=0.044). Notably, there were four cases of definite stent thrombosis (ST) with first vs. none with new-generation DES (p=0.044). Conclusions: In our study, new-generation DES had a trend for less MACE and improved results with regard to MI, TVR and definite ST at two-year follow-up.

Original languageEnglish (US)
Pages (from-to)809-816
Number of pages8
JournalEuroIntervention
Volume9
Issue number7
DOIs
StatePublished - Nov 2013
Externally publishedYes

Keywords

  • Drug-eluting stents
  • Percutaneous coronary intervention
  • Unprotected left main

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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