Two-step tuberculin skin testing in drug users

Shobha Swaminathan, Ellie Schoenbaum, Robert S. Klein, Andrea A. Howard, Yungtai Lo, Marc N. Gourevitch

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To assess the utility of booster testing and to identify factors associated with a positive booster test, two-step tuberculin testing was performed in drug users recruited from methadone treatment. Participants also received a standardized interview on demographics and testing for HIV and CD4+ lymphocyte count. Of 619 enrollees completing the protocol, 174 (28%) had a positive PPD and 24 of the remaining 445 (5%) had a positive booster test. On multivariate analysis, boosting was associated with older age (adjusted odds ratio [ORadj] 2.38/decade, 95% confidence interval [CI] 1.34-4.22), history of using crack cocaine (ORadj 2.61, 95% CI 1.10-6.18) and a history of working as a home health aide (ORadj 4.23, 95% CI 1.39-12.86). Two-step tuberculin skin testing increased the proportion of participants with latent tuberculosis infection from 22% to 25%. Given the effectiveness of chemoprophylaxis, booster testing should be considered when drug users are screened for tuberculosis infection.

Original languageEnglish (US)
Pages (from-to)71-79
Number of pages9
JournalJournal of Addictive Diseases
Volume26
Issue number2
DOIs
StatePublished - May 24 2007

Fingerprint

Tuberculin
Drug Users
Confidence Intervals
Skin
Home Health Aides
Crack Cocaine
Latent Tuberculosis
Methadone
Chemoprevention
CD4 Lymphocyte Count
Exercise Test
Tuberculosis
Multivariate Analysis
Odds Ratio
Demography
HIV
Interviews
Infection
Therapeutics

Keywords

  • Drug users
  • Skin testing
  • Tuberculosis

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Swaminathan, S., Schoenbaum, E., Klein, R. S., Howard, A. A., Lo, Y., & Gourevitch, M. N. (2007). Two-step tuberculin skin testing in drug users. Journal of Addictive Diseases, 26(2), 71-79. https://doi.org/10.1300/J069v26n02_09

Two-step tuberculin skin testing in drug users. / Swaminathan, Shobha; Schoenbaum, Ellie; Klein, Robert S.; Howard, Andrea A.; Lo, Yungtai; Gourevitch, Marc N.

In: Journal of Addictive Diseases, Vol. 26, No. 2, 24.05.2007, p. 71-79.

Research output: Contribution to journalArticle

Swaminathan, S, Schoenbaum, E, Klein, RS, Howard, AA, Lo, Y & Gourevitch, MN 2007, 'Two-step tuberculin skin testing in drug users', Journal of Addictive Diseases, vol. 26, no. 2, pp. 71-79. https://doi.org/10.1300/J069v26n02_09
Swaminathan, Shobha ; Schoenbaum, Ellie ; Klein, Robert S. ; Howard, Andrea A. ; Lo, Yungtai ; Gourevitch, Marc N. / Two-step tuberculin skin testing in drug users. In: Journal of Addictive Diseases. 2007 ; Vol. 26, No. 2. pp. 71-79.
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