Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility

Hongyan Chen, Gong Chen, Gang Li, Shuo Zhang, Haitao Chen, Yuanyuan Chen, Dave Duggan, Zhibin Hu, Juxing Chen, Yingjie Zhao, Yao Zhao, Huiling Huang, S. Lilly Zheng, Jeffrey M. Trent, Long Yu, Deke Jiang, Zengnan Mo, Hongwei Wang, Yonggao Mou, Tao JiangYing Mao, Jianfeng Xu, Daru Lu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Glioma is the most common malignant primary brain tumors with poor prognosis. Genome wide association studies (GWAS) of glioma in populations with Western European ancestry were completed in the US and UK. However, our previous results strongly suggest the genetic heterogeneity could be important in glioma risk. To systematically investigate glioma risk–associated variants in Chinese population, we performed a multistage GWAS of glioma in the Han Chinese population, with a total of 3,097 glioma cases and 4,362 controls. In addition to confirming two associations reported in other ancestry groups, this study identified one new risk-associated locus for glioma on chromosome 12p11.23 (rs10842893, pmeta = 2.33x10-12, STK38L) as well as a promising association at 15q15-21.1 (rs4774756, pmeta = 6.12x10-8, RAB27A) in 3,097 glioma cases and 4,362 controls. Our findings demonstrate two novel association between the glioma risk region marked by variant rs10842893 and rs4774756) and glioma risk. These findings may advance the understanding of genetic susceptibility to glioma.

Original languageEnglish (US)
Pages (from-to)2372-2382
Number of pages11
JournalInternational Journal of Cancer
Volume145
Issue number9
DOIs
StatePublished - Nov 2019
Externally publishedYes

Keywords

  • glioma
  • GWAS
  • oncogene
  • RAB27A
  • STK38L

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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