Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus

Michael R. Lerner; John A. Boyle; John A. Hardin; Joan A. Steitz

doi:10.1126/science.6164096

Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus

Michael R. Lerner, John A. Boyle, John A. Hardin, Joan A. Steitz

Medicine

Research output: Contribution to journal › Article › peer-review

352 Scopus citations

Abstract

The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins. The antigens Ro and La are also on ribonucleoproteins. The small RNA's in ribonucleoproteins with Ro are discrete, like those associated with RNP and Sm; in contrast, ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.

Original language	English (US)
Pages (from-to)	400-402
Number of pages	3
Journal	Science
Volume	211
Issue number	4480
DOIs	https://doi.org/10.1126/science.6164096
State	Published - 1981

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title = "Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus",

abstract = "The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins. The antigens Ro and La are also on ribonucleoproteins. The small RNA's in ribonucleoproteins with Ro are discrete, like those associated with RNP and Sm; in contrast, ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.",

author = "Lerner, {Michael R.} and Boyle, {John A.} and Hardin, {John A.} and Steitz, {Joan A.}",

year = "1981",

doi = "10.1126/science.6164096",

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AU - Lerner, Michael R.

AU - Boyle, John A.

AU - Hardin, John A.

AU - Steitz, Joan A.

PY - 1981

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N2 - The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins. The antigens Ro and La are also on ribonucleoproteins. The small RNA's in ribonucleoproteins with Ro are discrete, like those associated with RNP and Sm; in contrast, ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.

AB - The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins. The antigens Ro and La are also on ribonucleoproteins. The small RNA's in ribonucleoproteins with Ro are discrete, like those associated with RNP and Sm; in contrast, ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.

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Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus

Abstract

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