Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus

Michael R. Lerner, John A. Boyle, John A. Hardin, Joan A. Steitz

Research output: Contribution to journalArticle

344 Scopus citations

Abstract

The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins. The antigens Ro and La are also on ribonucleoproteins. The small RNA's in ribonucleoproteins with Ro are discrete, like those associated with RNP and Sm; in contrast, ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.

Original languageEnglish (US)
Pages (from-to)400-402
Number of pages3
JournalScience
Volume211
Issue number4480
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • General

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