Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus

Michael R. Lerner; John A. Boyle; John A. Hardin; Joan A. Steitz

doi:10.1126/science.6164096

Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus

Michael R. Lerner, John A. Boyle, John A. Hardin, Joan A. Steitz

Medicine

Research output: Contribution to journal › Article › peer-review

369 Scopus citations

Abstract

The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins. The antigens Ro and La are also on ribonucleoproteins. The small RNA's in ribonucleoproteins with Ro are discrete, like those associated with RNP and Sm; in contrast, ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.

Original language	English (US)
Pages (from-to)	400-402
Number of pages	3
Journal	Science
Volume	211
Issue number	4480
DOIs	https://doi.org/10.1126/science.6164096
State	Published - 1981

ASJC Scopus subject areas

General

Access to Document

10.1126/science.6164096

Cite this

@article{b7512d0033044f78830b27f19363395c,

title = "Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus",

abstract = "The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins. The antigens Ro and La are also on ribonucleoproteins. The small RNA's in ribonucleoproteins with Ro are discrete, like those associated with RNP and Sm; in contrast, ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.",

author = "Lerner, {Michael R.} and Boyle, {John A.} and Hardin, {John A.} and Steitz, {Joan A.}",

year = "1981",

doi = "10.1126/science.6164096",

language = "English (US)",

volume = "211",

pages = "400--402",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4480",

}

TY - JOUR

T1 - Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus

AU - Lerner, Michael R.

AU - Boyle, John A.

AU - Hardin, John A.

AU - Steitz, Joan A.

PY - 1981

Y1 - 1981

N2 - The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins. The antigens Ro and La are also on ribonucleoproteins. The small RNA's in ribonucleoproteins with Ro are discrete, like those associated with RNP and Sm; in contrast, ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.

AB - The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins. The antigens Ro and La are also on ribonucleoproteins. The small RNA's in ribonucleoproteins with Ro are discrete, like those associated with RNP and Sm; in contrast, ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.

UR - http://www.scopus.com/inward/record.url?scp=0019459464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019459464&partnerID=8YFLogxK

U2 - 10.1126/science.6164096

DO - 10.1126/science.6164096

M3 - Article

C2 - 6164096

AN - SCOPUS:0019459464

VL - 211

SP - 400

EP - 402

JO - Science

JF - Science

SN - 0036-8075

IS - 4480

ER -

Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this