Two chromosome aberrations in the child of a woman with systemic lupus erythematosus treated with azathioprine and prednisone

Harry Ostrer, J. Stamberg, P. Perinchief

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A boy with microcephaly, unusual facial features, micropenis, and growth retardation was born to a 30-year-old woman who took azathioprine and prednisone before and during pregnancy for systemic lupus erythematosus. The child has two apparently de novo chromosomal abnormalities: an apparently balanced translocation between chromosomes 6 and 14 and an interstitial deletion of chromosome 7. The karyotype is 46,XY,del(7)(q21);t(6;14)(q21;q12). Use of azathioprine and prednisone in pregnancy has been associated with intrauterine growth retardation, congenital malformations, and transient chromosome breaks in the blood of newborns. To our knowledge, this is the first report of de novo constitutional chromosome abnormalities in such an infant. We suggest that the assessment of infants born to parents treated with azathioprine should include a chromosome study, even if the infants seem to be normal.

Original languageEnglish (US)
Pages (from-to)627-632
Number of pages6
JournalAmerican Journal of Medical Genetics
Volume17
Issue number3
StatePublished - 1984
Externally publishedYes

Fingerprint

Azathioprine
Prednisone
Chromosome Aberrations
Systemic Lupus Erythematosus
Chromosomes, Human, Pair 14
Chromosome Breakage
Pregnancy
Microcephaly
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 7
Fetal Growth Retardation
Karyotype
Chromosomes
Parents
Newborn Infant
Growth

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Two chromosome aberrations in the child of a woman with systemic lupus erythematosus treated with azathioprine and prednisone. / Ostrer, Harry; Stamberg, J.; Perinchief, P.

In: American Journal of Medical Genetics, Vol. 17, No. 3, 1984, p. 627-632.

Research output: Contribution to journalArticle

@article{0ad5e4d5672d4bd191bb4e86a72dc510,
title = "Two chromosome aberrations in the child of a woman with systemic lupus erythematosus treated with azathioprine and prednisone",
abstract = "A boy with microcephaly, unusual facial features, micropenis, and growth retardation was born to a 30-year-old woman who took azathioprine and prednisone before and during pregnancy for systemic lupus erythematosus. The child has two apparently de novo chromosomal abnormalities: an apparently balanced translocation between chromosomes 6 and 14 and an interstitial deletion of chromosome 7. The karyotype is 46,XY,del(7)(q21);t(6;14)(q21;q12). Use of azathioprine and prednisone in pregnancy has been associated with intrauterine growth retardation, congenital malformations, and transient chromosome breaks in the blood of newborns. To our knowledge, this is the first report of de novo constitutional chromosome abnormalities in such an infant. We suggest that the assessment of infants born to parents treated with azathioprine should include a chromosome study, even if the infants seem to be normal.",
author = "Harry Ostrer and J. Stamberg and P. Perinchief",
year = "1984",
language = "English (US)",
volume = "17",
pages = "627--632",
journal = "American Journal of Medical Genetics, Part A",
issn = "1552-4825",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Two chromosome aberrations in the child of a woman with systemic lupus erythematosus treated with azathioprine and prednisone

AU - Ostrer, Harry

AU - Stamberg, J.

AU - Perinchief, P.

PY - 1984

Y1 - 1984

N2 - A boy with microcephaly, unusual facial features, micropenis, and growth retardation was born to a 30-year-old woman who took azathioprine and prednisone before and during pregnancy for systemic lupus erythematosus. The child has two apparently de novo chromosomal abnormalities: an apparently balanced translocation between chromosomes 6 and 14 and an interstitial deletion of chromosome 7. The karyotype is 46,XY,del(7)(q21);t(6;14)(q21;q12). Use of azathioprine and prednisone in pregnancy has been associated with intrauterine growth retardation, congenital malformations, and transient chromosome breaks in the blood of newborns. To our knowledge, this is the first report of de novo constitutional chromosome abnormalities in such an infant. We suggest that the assessment of infants born to parents treated with azathioprine should include a chromosome study, even if the infants seem to be normal.

AB - A boy with microcephaly, unusual facial features, micropenis, and growth retardation was born to a 30-year-old woman who took azathioprine and prednisone before and during pregnancy for systemic lupus erythematosus. The child has two apparently de novo chromosomal abnormalities: an apparently balanced translocation between chromosomes 6 and 14 and an interstitial deletion of chromosome 7. The karyotype is 46,XY,del(7)(q21);t(6;14)(q21;q12). Use of azathioprine and prednisone in pregnancy has been associated with intrauterine growth retardation, congenital malformations, and transient chromosome breaks in the blood of newborns. To our knowledge, this is the first report of de novo constitutional chromosome abnormalities in such an infant. We suggest that the assessment of infants born to parents treated with azathioprine should include a chromosome study, even if the infants seem to be normal.

UR - http://www.scopus.com/inward/record.url?scp=0021328818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021328818&partnerID=8YFLogxK

M3 - Article

C2 - 6711614

AN - SCOPUS:0021328818

VL - 17

SP - 627

EP - 632

JO - American Journal of Medical Genetics, Part A

JF - American Journal of Medical Genetics, Part A

SN - 1552-4825

IS - 3

ER -