Twisted protein aggregates are now implicated in diseases from Alzheimer's to sickle cell disease. In this work, it is argued that the twisted nature of the fibrils is an important feature in their (mis)design. It is demonstrated how twist effects may be fundamentally responsible for the metastability, and hence proliferation of, pathological sickle cell fibers.
|Original language||English (US)|
|Journal||Physical Review Letters|
|State||Published - Mar 28 2003|
ASJC Scopus subject areas
- Physics and Astronomy(all)