Twisted protein aggregates and disease: The stability of sickle hemoglobin fibers

M. S. Turner, R. W. Briehl, F. A. Ferrone, R. Josephs

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Twisted protein aggregates are now implicated in diseases from Alzheimer's to sickle cell disease. In this work, it is argued that the twisted nature of the fibrils is an important feature in their (mis)design. It is demonstrated how twist effects may be fundamentally responsible for the metastability, and hence proliferation of, pathological sickle cell fibers.

Original languageEnglish (US)
JournalPhysical Review Letters
Volume90
Issue number12
StatePublished - Mar 28 2003

Fingerprint

Sickle Hemoglobin
hemoglobin
Sickle Cell Anemia
Alzheimer Disease
proteins
fibers
cells
metastable state
Protein Aggregates

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Medicine(all)

Cite this

Turner, M. S., Briehl, R. W., Ferrone, F. A., & Josephs, R. (2003). Twisted protein aggregates and disease: The stability of sickle hemoglobin fibers. Physical Review Letters, 90(12).

Twisted protein aggregates and disease : The stability of sickle hemoglobin fibers. / Turner, M. S.; Briehl, R. W.; Ferrone, F. A.; Josephs, R.

In: Physical Review Letters, Vol. 90, No. 12, 28.03.2003.

Research output: Contribution to journalArticle

Turner, MS, Briehl, RW, Ferrone, FA & Josephs, R 2003, 'Twisted protein aggregates and disease: The stability of sickle hemoglobin fibers', Physical Review Letters, vol. 90, no. 12.
Turner, M. S. ; Briehl, R. W. ; Ferrone, F. A. ; Josephs, R. / Twisted protein aggregates and disease : The stability of sickle hemoglobin fibers. In: Physical Review Letters. 2003 ; Vol. 90, No. 12.
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