Twist of fate for acute promyelocytic leukemia: Trib3–TwIst1 interaction promotes resistance

Stephen Z. Peeke, Kira Gritsman

Research output: Contribution to journalArticle

Abstract

While acute promyelocytic leukemia has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance.

Original languageEnglish (US)
Pages (from-to)6018-6020
Number of pages3
JournalClinical Cancer Research
Volume25
Issue number20
DOIs
StatePublished - Oct 15 2019

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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