Twist of fate for acute promyelocytic leukemia: Trib3–TwIst1 interaction promotes resistance

Stephen Z. Peeke, Kira Gritsman

Research output: Contribution to journal › Article

Abstract

While acute promyelocytic leukemia has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance.

Original languageEnglish (US)
Pages (from-to)6018-6020
Number of pages3
JournalClinical Cancer Research
Volume25
Issue number20
DOIs
StatePublished - Oct 15 2019

Fingerprint

Acute Promyelocytic Leukemia
Tretinoin
Peptides

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Twist of fate for acute promyelocytic leukemia : Trib3–TwIst1 interaction promotes resistance. / Peeke, Stephen Z.; Gritsman, Kira.

In: Clinical Cancer Research, Vol. 25, No. 20, 15.10.2019, p. 6018-6020.

Research output: Contribution to journal › Article

Peeke, SZ & Gritsman, K 2019, 'Twist of fate for acute promyelocytic leukemia: Trib3–TwIst1 interaction promotes resistance', Clinical Cancer Research, vol. 25, no. 20, pp. 6018-6020. https://doi.org/10.1158/1078-0432.CCR-19-2140
Peeke SZ, Gritsman K. Twist of fate for acute promyelocytic leukemia: Trib3–TwIst1 interaction promotes resistance. Clinical Cancer Research. 2019 Oct 15;25(20):6018-6020. https://doi.org/10.1158/1078-0432.CCR-19-2140
Peeke, Stephen Z. ; Gritsman, Kira. / Twist of fate for acute promyelocytic leukemia : Trib3–TwIst1 interaction promotes resistance. In: Clinical Cancer Research. 2019 ; Vol. 25, No. 20. pp. 6018-6020.
@article{bfc462df678a405cafcfd3778e9f3378,
title = "Twist of fate for acute promyelocytic leukemia: Trib3–TwIst1 interaction promotes resistance",
abstract = "While acute promyelocytic leukemia has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance.",
author = "Peeke, {Stephen Z.} and Kira Gritsman",
year = "2019",
month = "10",
day = "15",
doi = "10.1158/1078-0432.CCR-19-2140",
language = "English (US)",
volume = "25",
pages = "6018--6020",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "20",

}

TY - JOUR

T1 - Twist of fate for acute promyelocytic leukemia

T2 - Trib3–TwIst1 interaction promotes resistance

AU - Peeke, Stephen Z.

AU - Gritsman, Kira

PY - 2019/10/15

Y1 - 2019/10/15

N2 - While acute promyelocytic leukemia has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance.

AB - While acute promyelocytic leukemia has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance.

UR - http://www.scopus.com/inward/record.url?scp=85073307158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073307158&partnerID=8YFLogxK

U2 - 10.1158/1078-0432.CCR-19-2140

DO - 10.1158/1078-0432.CCR-19-2140

M3 - Article

C2 - 31405833

AN - SCOPUS:85073307158

VL - 25

SP - 6018

EP - 6020

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 20

ER -

Access to Document