Twist of fate for acute promyelocytic leukemia: Trib3–TwIst1 interaction promotes resistance

Stephen Z. Peeke; Kira Gritsman

doi:10.1158/1078-0432.CCR-19-2140

Twist of fate for acute promyelocytic leukemia: Trib3–TwIst1 interaction promotes resistance

Stephen Z. Peeke, Kira Gritsman

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

While acute promyelocytic leukemia has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance.

Original language	English (US)
Pages (from-to)	6018-6020
Number of pages	3
Journal	Clinical Cancer Research
Volume	25
Issue number	20
DOIs	https://doi.org/10.1158/1078-0432.CCR-19-2140
State	Published - Oct 15 2019

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Twist of fate for acute promyelocytic leukemia: Trib3–TwIst1 interaction promotes resistance",

abstract = "While acute promyelocytic leukemia has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance.",

author = "Peeke, {Stephen Z.} and Kira Gritsman",

note = "Funding Information: This work was supported by NCI R01 CA196973 (to K. Gritsman).",

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AB - While acute promyelocytic leukemia has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance.

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