Twelve-Year Trend in the Prevalence of High-Risk Human Papillomavirus Infection Among Rwandan Women Living With HIV

Gad Murenzi, Faustin Kanyabwisha, Anthere Murangwa, Gallican Kubwimana, Leon Mutesa, Robert D. Burk, Kathryn Anastos, Philip E. Castle

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

BACKGROUND: We examined the trend in prevalence of high-risk human papillomavirus (hrHPV) cervical infection among Rwandan women living with HIV (WLWH) over 12 years. METHODS: Prevalence of cervical hrHPV DNA was measured in 3 studies at 3 different time periods in 3 different groups of WLWH using 3 different but comparable hrHPV tests: a MY09/MY11 PCR test in 2005 (RWISA; n = 497), careHPV in 2009-2010 (HPV Demonstration; n = 1242), and Xpert HPV test in 2016-2018 (U54; n = 4734). Prevalences were adjusted for age and CD4 cell count. RESULTS: HrHPV prevalence decreased over time from 42.5% to 32.2% to 26.5% (P < .001). CD4 cell counts improved over time (Ptrend <.001) so that the percentage of WLWH with CD4 counts of ≥500 cells/μL increased from 7.7% in 2005 to 42.2% in 2009-2010 and 61.1% in 2016-2018. Thus, after adjustment for differences in CD4 counts and age, hrHPV prevalences were more similar over time: 32.6% for RWISA, 30.6% for HPV Demonstration, and 27.1% for U54 (P = .007). CONCLUSIONS: Prevalence of hrHPV among WLWH has decreased over the past decade, most likely the result of improved immune reconstitution due to better HIV care and management in Rwanda.

Original languageEnglish (US)
Pages (from-to)74-81
Number of pages8
JournalThe Journal of infectious diseases
Volume222
Issue number1
DOIs
StatePublished - Jun 16 2020

Keywords

  • CD4
  • Rwanda
  • antiretroviral therapy (ART)
  • cervical cancer
  • human immunodeficiency virus (HIV)
  • human papillomavirus (HPV)
  • sub-Saharan Africa

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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