Abstract
Recent studies in diverse organisms implicate proto-oncogenic pathways, including insulin-like growth factor-I (IGF-I), Ras and AKT/protein kinase B in the ageing process. Although IGF-I is thought to contribute to cancer by promoting growth and preventing apoptosis, evidence from model organisms suggests that proto-oncogene homologues might contribute to the DNA mutations and chromosomal damage that are observed in tumour cells by increasing DNA damage, in both dividing and non-dividing cells, and involving error-prone systems in DNA repair. This raises the possibility that cancer can be reduced by chronic downregulation of pro-ageing pathways.
Original language | English (US) |
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Pages (from-to) | 903-910 |
Number of pages | 8 |
Journal | Nature Reviews Molecular Cell Biology |
Volume | 9 |
Issue number | 11 |
DOIs |
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State | Published - Nov 2008 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology