Turning anti-ageing genes against cancer

Valter D. Longo, Michael R. Lieber, Jan Vijg

Research output: Contribution to journalComment/debate

29 Scopus citations

Abstract

Recent studies in diverse organisms implicate proto-oncogenic pathways, including insulin-like growth factor-I (IGF-I), Ras and AKT/protein kinase B in the ageing process. Although IGF-I is thought to contribute to cancer by promoting growth and preventing apoptosis, evidence from model organisms suggests that proto-oncogene homologues might contribute to the DNA mutations and chromosomal damage that are observed in tumour cells by increasing DNA damage, in both dividing and non-dividing cells, and involving error-prone systems in DNA repair. This raises the possibility that cancer can be reduced by chronic downregulation of pro-ageing pathways.

Original languageEnglish (US)
Pages (from-to)903-910
Number of pages8
JournalNature Reviews Molecular Cell Biology
Volume9
Issue number11
DOIs
StatePublished - Nov 1 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Turning anti-ageing genes against cancer'. Together they form a unique fingerprint.

  • Cite this