Tunneling nanotubes (TNT)

A potential mechanism for intercellular trafficking of HIV

Eliseo A. Eugenin, Peter J. Gaskill, Joan W. Berman

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Cell-to-cell communication coordinates the development of multicellular systems, and is mediated by soluble factors, gap junctions and the recently described tunneling nanotubes (TNT). Both TNT and gap junctions facilitate the transfer of intracellular mediators between the cytoplasm of connected cells. We recently described that HIV induced the formation of TNT in human primary macrophages in correlation with viral replication. Based on these results we hypothesized that during HIV infection, TNTs are hijacked by HIV to spread infection. TNT like structures may be a novel mechanism of amplification of HIV infection. Our findings and those of others require further investigation to identify the specific mechanisms by which pathogens use TNT.

Original languageEnglish (US)
Pages (from-to)243-244
Number of pages2
JournalCommunicative and Integrative Biology
Volume2
Issue number3
DOIs
StatePublished - May 2009

Fingerprint

nanotubes
Nanotubes
HIV
gap junctions
Gap Junctions
HIV infections
HIV Infections
Trinitrotoluene
cell communication
virus replication
Cell Communication
Cytoplasm
macrophages
cytoplasm
Macrophages
pathogens
Infection
infection

Keywords

  • AIDS
  • Communication
  • Connexin
  • Filopodia
  • HIV
  • Inflammation
  • Macrophages

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Tunneling nanotubes (TNT) : A potential mechanism for intercellular trafficking of HIV. / Eugenin, Eliseo A.; Gaskill, Peter J.; Berman, Joan W.

In: Communicative and Integrative Biology, Vol. 2, No. 3, 05.2009, p. 243-244.

Research output: Contribution to journalArticle

@article{80778abccf994107b62b845c7845ab88,
title = "Tunneling nanotubes (TNT): A potential mechanism for intercellular trafficking of HIV",
abstract = "Cell-to-cell communication coordinates the development of multicellular systems, and is mediated by soluble factors, gap junctions and the recently described tunneling nanotubes (TNT). Both TNT and gap junctions facilitate the transfer of intracellular mediators between the cytoplasm of connected cells. We recently described that HIV induced the formation of TNT in human primary macrophages in correlation with viral replication. Based on these results we hypothesized that during HIV infection, TNTs are hijacked by HIV to spread infection. TNT like structures may be a novel mechanism of amplification of HIV infection. Our findings and those of others require further investigation to identify the specific mechanisms by which pathogens use TNT.",
keywords = "AIDS, Communication, Connexin, Filopodia, HIV, Inflammation, Macrophages",
author = "Eugenin, {Eliseo A.} and Gaskill, {Peter J.} and Berman, {Joan W.}",
year = "2009",
month = "5",
doi = "10.4161/cib.2.3.8165",
language = "English (US)",
volume = "2",
pages = "243--244",
journal = "Communicative and Integrative Biology",
issn = "1942-0889",
publisher = "Landes Bioscience",
number = "3",

}

TY - JOUR

T1 - Tunneling nanotubes (TNT)

T2 - A potential mechanism for intercellular trafficking of HIV

AU - Eugenin, Eliseo A.

AU - Gaskill, Peter J.

AU - Berman, Joan W.

PY - 2009/5

Y1 - 2009/5

N2 - Cell-to-cell communication coordinates the development of multicellular systems, and is mediated by soluble factors, gap junctions and the recently described tunneling nanotubes (TNT). Both TNT and gap junctions facilitate the transfer of intracellular mediators between the cytoplasm of connected cells. We recently described that HIV induced the formation of TNT in human primary macrophages in correlation with viral replication. Based on these results we hypothesized that during HIV infection, TNTs are hijacked by HIV to spread infection. TNT like structures may be a novel mechanism of amplification of HIV infection. Our findings and those of others require further investigation to identify the specific mechanisms by which pathogens use TNT.

AB - Cell-to-cell communication coordinates the development of multicellular systems, and is mediated by soluble factors, gap junctions and the recently described tunneling nanotubes (TNT). Both TNT and gap junctions facilitate the transfer of intracellular mediators between the cytoplasm of connected cells. We recently described that HIV induced the formation of TNT in human primary macrophages in correlation with viral replication. Based on these results we hypothesized that during HIV infection, TNTs are hijacked by HIV to spread infection. TNT like structures may be a novel mechanism of amplification of HIV infection. Our findings and those of others require further investigation to identify the specific mechanisms by which pathogens use TNT.

KW - AIDS

KW - Communication

KW - Connexin

KW - Filopodia

KW - HIV

KW - Inflammation

KW - Macrophages

UR - http://www.scopus.com/inward/record.url?scp=77953715480&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953715480&partnerID=8YFLogxK

U2 - 10.4161/cib.2.3.8165

DO - 10.4161/cib.2.3.8165

M3 - Article

VL - 2

SP - 243

EP - 244

JO - Communicative and Integrative Biology

JF - Communicative and Integrative Biology

SN - 1942-0889

IS - 3

ER -