Tumor-stroma

In vivo assays and intravital imaging to study cell migration and metastasis

Zhen Ni Zhou, Pamela J. Boimel, Jeffrey E. Segall

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The development of metastatic disease is often correlated with poor patient outcome in a variety of different cancers. The metastatic cascade is a complex, multistep process that involves the growth of the primary tumor and angiogenesis, invasion into the local environment, intravasation into the vasculature, tumor cell survival in the circulation, extravasation from the vasculature and sustained growth at secondary organ sites to form metastases. Although in vitro assays of single cell types can provide information regarding cell autonomous mechanisms contributing to metastasis, the in vivo microenvironment entails a network of interactions between cells which is also important. Insight into the mechanisms underlying tumor cell migration, invasion and metastasis in vivo has been aided by development of multiphoton microscopy and in vivo assays, which we will review here.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalDrug Discovery Today: Disease Models
Volume8
Issue number2-3
DOIs
StatePublished - Sep 2011
Externally publishedYes

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Cell Movement
Neoplasm Metastasis
Neoplasms
Growth
Cell Communication
Cell Survival
Intravital Microscopy

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

Cite this

Tumor-stroma : In vivo assays and intravital imaging to study cell migration and metastasis. / Zhou, Zhen Ni; Boimel, Pamela J.; Segall, Jeffrey E.

In: Drug Discovery Today: Disease Models, Vol. 8, No. 2-3, 09.2011, p. 95-102.

Research output: Contribution to journalArticle

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