TY - JOUR
T1 - Tumor-stroma
T2 - In vivo assays and intravital imaging to study cell migration and metastasis
AU - Zhou, Zhen Ni
AU - Boimel, Pamela J.
AU - Segall, Jeffrey E.
N1 - Funding Information:
Financial support: This work was supported by grants CA77522 and CA100324 from the NIH .
PY - 2011
Y1 - 2011
N2 - The development of metastatic disease is often correlated with poor patient outcome in a variety of different cancers. The metastatic cascade is a complex, multistep process that involves the growth of the primary tumor and angiogenesis, invasion into the local environment, intravasation into the vasculature, tumor cell survival in the circulation, extravasation from the vasculature and sustained growth at secondary organ sites to form metastases. Although in vitro assays of single cell types can provide information regarding cell autonomous mechanisms contributing to metastasis, the in vivo microenvironment entails a network of interactions between cells which is also important. Insight into the mechanisms underlying tumor cell migration, invasion and metastasis in vivo has been aided by development of multiphoton microscopy and in vivo assays, which we will review here.
AB - The development of metastatic disease is often correlated with poor patient outcome in a variety of different cancers. The metastatic cascade is a complex, multistep process that involves the growth of the primary tumor and angiogenesis, invasion into the local environment, intravasation into the vasculature, tumor cell survival in the circulation, extravasation from the vasculature and sustained growth at secondary organ sites to form metastases. Although in vitro assays of single cell types can provide information regarding cell autonomous mechanisms contributing to metastasis, the in vivo microenvironment entails a network of interactions between cells which is also important. Insight into the mechanisms underlying tumor cell migration, invasion and metastasis in vivo has been aided by development of multiphoton microscopy and in vivo assays, which we will review here.
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U2 - 10.1016/j.ddmod.2011.07.003
DO - 10.1016/j.ddmod.2011.07.003
M3 - Review article
AN - SCOPUS:82455199249
SN - 1740-6757
VL - 8
SP - 95
EP - 102
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
IS - 2-3
ER -