Tumor necrosis factor-α in pediatric HIV-1 infection

Maadhava Ellaurie, Arye Rubinstein

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Objective: To evaluate the diagnostic and prognostic value of serum tumor necrosis factor-α (TNF-α) levels in HIV-1-infected children. Design: Serum levels of TNF-α were evaluated in 57 HIV-1-infected symptomatic children aged between 7 months and 8 years. Methods: TNF-α levels were determined by enzyme immunoassay. The sensitivity of the assay was 10 pg/ml. Results: TNF-α levels (mean ± s.d.) were significantly elevated in HIV-1-infected patients (285 ± 390 pg/ml), compared with HIV-1-uninfected age-matched controls (22.7 ± 4.9 pg/ml). Among HIV-1-infected children the highest levels of TNF-α were noted in those with Mycobacterium avium intracellulare (MAI) infection and those with interstitial lymphoid pneumonitis (LIP). In contrast, patients with Pneumocystis carinii pneumonia, progressive encephalopathy or cachexia did not have markedly elevated TNF-α levels. Conclusions: Serum TNF-α is increased in symptomatic HIV-1-infected children, with higher levels in children with LIP or MAI. Serum TNF-α levels are not diagnostic for cachexia or progressive encephalopathy.

Original languageEnglish (US)
Pages (from-to)1265-1268
Number of pages4
JournalAIDS
Volume6
Issue number11
DOIs
StatePublished - Nov 1992

Keywords

  • HIV-1
  • Interstitial lymphoid pneumonitis
  • Mycobacterium avium intracellulare
  • Pneumocystis carinii pneumonia
  • Pulmonary lymphoid hyperplasia
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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