Tumor Cholesterol Up, T Cells Down

Elodie Picarda; Xiaoxin Ren; Xingxing Zang

doi:10.1016/j.cmet.2019.06.007

Tumor Cholesterol Up, T Cells Down

Elodie Picarda, Xiaoxin Ren, Xingxing Zang

Microbiology & Immunology

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

Original language	English (US)
Pages (from-to)	12-13
Number of pages	2
Journal	Cell metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2019.06.007
State	Published - Jul 2 2019

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2019.06.007

Cite this

@article{9321c39c7e6a4faf911d003c49fdb611,

title = "Tumor Cholesterol Up, T Cells Down",

abstract = "Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.",

author = "Elodie Picarda and Xiaoxin Ren and Xingxing Zang",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jul,

day = "2",

doi = "10.1016/j.cmet.2019.06.007",

language = "English (US)",

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journal = "Cell metabolism",

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TY - JOUR

T1 - Tumor Cholesterol Up, T Cells Down

AU - Picarda, Elodie

AU - Ren, Xiaoxin

AU - Zang, Xingxing

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

AB - Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

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U2 - 10.1016/j.cmet.2019.06.007

DO - 10.1016/j.cmet.2019.06.007

M3 - Short survey

C2 - 31269422

AN - SCOPUS:85067353514

SN - 1550-4131

VL - 30

SP - 12

EP - 13

JO - Cell metabolism

JF - Cell metabolism

IS - 1

ER -

Tumor Cholesterol Up, T Cells Down

Abstract

ASJC Scopus subject areas

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