Tumor Cholesterol Up, T Cells Down

Elodie Picarda; Xiaoxin Ren; Xingxing Zang

doi:10.1016/j.cmet.2019.06.007

Tumor Cholesterol Up, T Cells Down

Elodie Picarda, Xiaoxin Ren, Xingxing Zang

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

Original language	English (US)
Pages (from-to)	12-13
Number of pages	2
Journal	Cell metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2019.06.007
State	Published - Jul 2 2019
Externally published	Yes

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

Access to Document

10.1016/j.cmet.2019.06.007

Cite this

@article{9321c39c7e6a4faf911d003c49fdb611,

title = "Tumor Cholesterol Up, T Cells Down",

abstract = "Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.",

author = "Elodie Picarda and Xiaoxin Ren and Xingxing Zang",

note = "Funding Information: This work was supported by NIH grants R01DK100525 and R01CA175495 and Irma T. Hirschl /Monique Weill-Caulier Trust. Funding Information: This work was supported by NIH grants R01DK100525 and R01CA175495 and Irma T. Hirschl/Monique Weill-Caulier Trust. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jul,

day = "2",

doi = "10.1016/j.cmet.2019.06.007",

language = "English (US)",

volume = "30",

pages = "12--13",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "1",

}

TY - JOUR

T1 - Tumor Cholesterol Up, T Cells Down

AU - Picarda, Elodie

AU - Ren, Xiaoxin

AU - Zang, Xingxing

N1 - Funding Information: This work was supported by NIH grants R01DK100525 and R01CA175495 and Irma T. Hirschl /Monique Weill-Caulier Trust. Funding Information: This work was supported by NIH grants R01DK100525 and R01CA175495 and Irma T. Hirschl/Monique Weill-Caulier Trust. Publisher Copyright: © 2019 Elsevier Inc.

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

AB - Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

UR - http://www.scopus.com/inward/record.url?scp=85067353514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067353514&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2019.06.007

DO - 10.1016/j.cmet.2019.06.007

M3 - Short survey

C2 - 31269422

AN - SCOPUS:85067353514

VL - 30

SP - 12

EP - 13

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 1

ER -

Tumor Cholesterol Up, T Cells Down

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this