Tumor Cholesterol Up, T Cells Down

Elodie Picarda; Xiaoxin Ren; Xingxing Zang

doi:10.1016/j.cmet.2019.06.007

Tumor Cholesterol Up, T Cells Down

Elodie Picarda, Xiaoxin Ren, Xingxing Zang

Microbiology & Immunology

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

Original language	English (US)
Pages (from-to)	12-13
Number of pages	2
Journal	Cell metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2019.06.007
State	Published - Jul 2 2019

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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title = "Tumor Cholesterol Up, T Cells Down",

abstract = "Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.",

author = "Elodie Picarda and Xiaoxin Ren and Xingxing Zang",

note = "Funding Information: This work was supported by NIH grants R01DK100525 and R01CA175495 and Irma T. Hirschl /Monique Weill-Caulier Trust. Funding Information: This work was supported by NIH grants R01DK100525 and R01CA175495 and Irma T. Hirschl/Monique Weill-Caulier Trust.",

year = "2019",

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doi = "10.1016/j.cmet.2019.06.007",

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T1 - Tumor Cholesterol Up, T Cells Down

AU - Picarda, Elodie

AU - Ren, Xiaoxin

AU - Zang, Xingxing

N1 - Funding Information: This work was supported by NIH grants R01DK100525 and R01CA175495 and Irma T. Hirschl /Monique Weill-Caulier Trust. Funding Information: This work was supported by NIH grants R01DK100525 and R01CA175495 and Irma T. Hirschl/Monique Weill-Caulier Trust.

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

AB - Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

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