Tumor Cholesterol Up, T Cells Down

Elodie Picarda; Xiaoxin Ren; Xingxing Zang

doi:10.1016/j.cmet.2019.06.007

Tumor Cholesterol Up, T Cells Down

Elodie Picarda, Xiaoxin Ren, Xingxing Zang

Microbiology & Immunology

Research output: Contribution to journal › Short survey

1 Scopus citations

Abstract

Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

Original language	English (US)
Pages (from-to)	12-13
Number of pages	2
Journal	Cell metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2019.06.007
State	Published - Jul 2 2019

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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Picarda, E., Ren, X., & Zang, X. (2019). Tumor Cholesterol Up, T Cells Down. Cell metabolism, 30(1), 12-13. https://doi.org/10.1016/j.cmet.2019.06.007

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abstract = "Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.",

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