Tumor Cholesterol Up, T Cells Down

Elodie Picarda, Xiaoxin Ren, Xingxing Zang

Research output: Contribution to journalShort survey

Abstract

Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

Original languageEnglish (US)
Pages (from-to)12-13
Number of pages2
JournalCell metabolism
Volume30
Issue number1
DOIs
Publication statusPublished - Jul 2 2019

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ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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