Abstract
Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.
Original language | English (US) |
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Pages (from-to) | 12-13 |
Number of pages | 2 |
Journal | Cell metabolism |
Volume | 30 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2 2019 |
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ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cell Biology
Cite this
Tumor Cholesterol Up, T Cells Down. / Picarda, Elodie; Ren, Xiaoxin; Zang, Xingxing.
In: Cell metabolism, Vol. 30, No. 1, 02.07.2019, p. 12-13.Research output: Contribution to journal › Short survey
}
TY - JOUR
T1 - Tumor Cholesterol Up, T Cells Down
AU - Picarda, Elodie
AU - Ren, Xiaoxin
AU - Zang, Xingxing
PY - 2019/7/2
Y1 - 2019/7/2
N2 - Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.
AB - Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.
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UR - http://www.scopus.com/inward/citedby.url?scp=85067353514&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2019.06.007
DO - 10.1016/j.cmet.2019.06.007
M3 - Short survey
C2 - 31269422
AN - SCOPUS:85067353514
VL - 30
SP - 12
EP - 13
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 1
ER -