Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction

Maria De Nazareth Leal De Meirelles, Mirian Claudia S. Pereira, Robert H. Singer, Maria De Nazaré C. Soeiro, Luciana R. Garzoni, Dayse T. Silva, Helene S. Barbosa, Tania C. Araujo-Jorge, Masako O. Masuda, Marcia A.M. Capella, Anibal Gil Lopes, Alane B. Vermelho

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The present paper summarizes new approaches regarding the progress done to the understanding of the interaction of Trypanosoma cruzi-cardiomyocytes. Mannose receptors localized at the surface of heart muscle cell are involved in binding and uptake of the parasite. One of the most striking events in the parasite-heart muscle cells interaction is the disruption of the actin cytoskeleton. We have investigated the regulation of the actin mRNA during the cytopathology induced in myocardial cells by the parasite. T. cruzi invasion increases calcium resting levels in cardiomyocytes. We have previously shown that Ca2+ ATPase of the sarcoplasmic reticulum (SERCA) is involved in the invasion of T. cruzi in cardiomyocytes. Treating the cells with thapsigargin, a drug that binds to all SERCA ATPases and causes depletion of intracellular calcium stores, we found a 75% inhibition in the T. cruzi-cardiomyocytes invasion.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalMemorias do Instituto Oswaldo Cruz
Volume94
Issue numberSUPPL. 1
DOIs
StatePublished - 1999

Keywords

  • Calcium
  • Cardiomyocytes
  • Mannose receptor
  • SERCA ATPases
  • Trypanosoma cruzi
  • mRNA regulation

ASJC Scopus subject areas

  • Microbiology (medical)

Fingerprint Dive into the research topics of 'Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction'. Together they form a unique fingerprint.

  • Cite this

    De Meirelles, M. D. N. L., Pereira, M. C. S., Singer, R. H., Soeiro, M. D. N. C., Garzoni, L. R., Silva, D. T., Barbosa, H. S., Araujo-Jorge, T. C., Masuda, M. O., Capella, M. A. M., Lopes, A. G., & Vermelho, A. B. (1999). Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction. Memorias do Instituto Oswaldo Cruz, 94(SUPPL. 1), 149-152. https://doi.org/10.1590/s0074-02761999000700017