Abstract
The course of infection due to Trypanosoma brucei infection was observed in genetically diabetic and streptozotocin-induced diabetic mice. A strain of T. brucei, TREU 667, was used which produces a chronic infection in C57BL 6(B6) mice lasting greater than 60 days. Genetic diabetic mice ( +db +db) are obese, and have elevated blood glucose levels, normal levels of insulin, and impaired cell-mediated immunity. Their littermates ( m+ m+, m+ +db) are of normal weight, and are normoglycemic and immunocompetent. The infected +db +db mice lived significantly longer than the nondiabetic littermates. In contrast to this finding, streptozotocin-induced diabetic B6 mice developed higher parasitemia and had shorter survival times than control B6 mice. Continuous treatment with insulin of these streptozotocininduced diabetic mice led to normalization of blood glucose and a significant reduction of parasitemia. While hyperglycemia may be associated with higher parasitemia and death in streptozotozin-induced diabetes, genetic factors may play an additional role in the genetic models.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 342-347 |
| Number of pages | 6 |
| Journal | Experimental Parasitology |
| Volume | 60 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1985 |
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Keywords
- Diabetes mellitus
- Diabetic mice
- Trypanosoma brucei
- Trypanosomiasis
ASJC Scopus subject areas
- Immunology
- Parasitology
- Infectious Diseases
Cite this
Trypanosoma brucei : Infection in murine diabetes. / Amole, Babatunde O.; Wittner, Murray; Hewlett, Dial; Tanowitz, Herbert B.
In: Experimental Parasitology, Vol. 60, No. 3, 1985, p. 342-347.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Trypanosoma brucei
T2 - Infection in murine diabetes
AU - Amole, Babatunde O.
AU - Wittner, Murray
AU - Hewlett, Dial
AU - Tanowitz, Herbert B.
PY - 1985
Y1 - 1985
N2 - The course of infection due to Trypanosoma brucei infection was observed in genetically diabetic and streptozotocin-induced diabetic mice. A strain of T. brucei, TREU 667, was used which produces a chronic infection in C57BL 6(B6) mice lasting greater than 60 days. Genetic diabetic mice ( +db +db) are obese, and have elevated blood glucose levels, normal levels of insulin, and impaired cell-mediated immunity. Their littermates ( m+ m+, m+ +db) are of normal weight, and are normoglycemic and immunocompetent. The infected +db +db mice lived significantly longer than the nondiabetic littermates. In contrast to this finding, streptozotocin-induced diabetic B6 mice developed higher parasitemia and had shorter survival times than control B6 mice. Continuous treatment with insulin of these streptozotocininduced diabetic mice led to normalization of blood glucose and a significant reduction of parasitemia. While hyperglycemia may be associated with higher parasitemia and death in streptozotozin-induced diabetes, genetic factors may play an additional role in the genetic models.
AB - The course of infection due to Trypanosoma brucei infection was observed in genetically diabetic and streptozotocin-induced diabetic mice. A strain of T. brucei, TREU 667, was used which produces a chronic infection in C57BL 6(B6) mice lasting greater than 60 days. Genetic diabetic mice ( +db +db) are obese, and have elevated blood glucose levels, normal levels of insulin, and impaired cell-mediated immunity. Their littermates ( m+ m+, m+ +db) are of normal weight, and are normoglycemic and immunocompetent. The infected +db +db mice lived significantly longer than the nondiabetic littermates. In contrast to this finding, streptozotocin-induced diabetic B6 mice developed higher parasitemia and had shorter survival times than control B6 mice. Continuous treatment with insulin of these streptozotocininduced diabetic mice led to normalization of blood glucose and a significant reduction of parasitemia. While hyperglycemia may be associated with higher parasitemia and death in streptozotozin-induced diabetes, genetic factors may play an additional role in the genetic models.
KW - Diabetes mellitus
KW - Diabetic mice
KW - Trypanosoma brucei
KW - Trypanosomiasis
UR - http://www.scopus.com/inward/record.url?scp=0022393216&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022393216&partnerID=8YFLogxK
U2 - 10.1016/0014-4894(85)90040-2
DO - 10.1016/0014-4894(85)90040-2
M3 - Article
C2 - 4076389
AN - SCOPUS:0022393216
VL - 60
SP - 342
EP - 347
JO - Experimental Parasitology
JF - Experimental Parasitology
SN - 0014-4894
IS - 3
ER -