Trisomy 22-A new abnormality found in acute leukemia characterized by eosinophilia and monocytoid blasts expressing immature differentiation antigens

Vesna Najfeld, Stephanie Seremetis, Kevin Troy, Joan Uehlinger, Paula Schwartz, Janet Cuttner

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Bone marrow cells from three patients with acute myeloid leukemia, with marrow eosinophilia and monocytoid blasts, showed a new nonrandom chromosomal abnormality, trisomy 22. In two patients the classification of leukemia was M4 and in the third patient M2 (FAB classification). Pretreatment bone marrows in these patients revealed 31%, 30%, and 4% eosinophils, respectively. Blast cells isolated from peripheral blood were Ia-positive and expressed immature monocyte lineage antigens (U26, U28, U48) in 26%-92% of cells. All three patients had a population of bone marrow cells characterized by an extra chromosome #22. One patient also had inversion of chromosome #16. Trisomy 22, bone marrow eosinophilia, and monocytoid blasts displaying early monocyte differentiation antigens may represent a new subgroup of patients with acute myeloid leukemia.

Original languageEnglish (US)
Pages (from-to)105-114
Number of pages10
JournalCancer Genetics and Cytogenetics
Volume23
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

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Differentiation Antigens
Eosinophilia
Leukemia
Bone Marrow
Acute Myeloid Leukemia
Bone Marrow Cells
Monocytes
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 22
Trisomy Chromosome 22
Eosinophils
Chromosome Aberrations
Antigens
Population

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Trisomy 22-A new abnormality found in acute leukemia characterized by eosinophilia and monocytoid blasts expressing immature differentiation antigens. / Najfeld, Vesna; Seremetis, Stephanie; Troy, Kevin; Uehlinger, Joan; Schwartz, Paula; Cuttner, Janet.

In: Cancer Genetics and Cytogenetics, Vol. 23, No. 2, 1986, p. 105-114.

Research output: Contribution to journalArticle

Najfeld, Vesna ; Seremetis, Stephanie ; Troy, Kevin ; Uehlinger, Joan ; Schwartz, Paula ; Cuttner, Janet. / Trisomy 22-A new abnormality found in acute leukemia characterized by eosinophilia and monocytoid blasts expressing immature differentiation antigens. In: Cancer Genetics and Cytogenetics. 1986 ; Vol. 23, No. 2. pp. 105-114.
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AU - Uehlinger, Joan

AU - Schwartz, Paula

AU - Cuttner, Janet

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