Triiodothyronine stimulates growth of cultured GC cells by action early in the G1 period

C. R. DeFesi, E. C. Fels, Martin I. Surks

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

T3 regulates the proliferation rate of GC cells, a rat GH-secreting pituitary tumor cell line, by modulating the duration of the G1 period. In GC cells which were synchronized at the beginning of G1 by mitotic selection, the G1 period was 11.7± (SE)2.1 h, in agreement with the value was obtained in asynchronous cells by other methods (10.0+0.9 h). G1 was significantly prolonged in synchronized GC cells, previously maintained in the absence of T3 for more than 1 cycle time. G1 duration decreased when cells were exposed to T3 only during a discrete 4-6 h interval early in G1. Thus T3 appeared to stimulate progression through the G1 period by action early in G1.

Original languageEnglish (US)
Pages (from-to)293-295
Number of pages3
JournalEndocrinology
Volume114
Issue number1
StatePublished - 1984

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Triiodothyronine
Cultured Cells
Growth
Pituitary Neoplasms
Tumor Cell Line

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Triiodothyronine stimulates growth of cultured GC cells by action early in the G1 period. / DeFesi, C. R.; Fels, E. C.; Surks, Martin I.

In: Endocrinology, Vol. 114, No. 1, 1984, p. 293-295.

Research output: Contribution to journalArticle

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