TY - JOUR
T1 - Trial of antihypertensive interventions and management. Design, methods, and selected baseline results
AU - R. Davis, Barry
AU - Blaufox, M. Donald
AU - Hawkins, C. Morton
AU - Langford, Herbert G.
AU - Oberman, Albert
AU - Swencionis, Charles
AU - Wassertheil-Smoller, Sylvia
AU - Wylie-Rosett, Judy
AU - Zimbaldi, Neal
N1 - Funding Information:
Reports from the Hypertension Detection and Follow-up Program \[1,2\] supported by studies from Australia \[3\] and Norway \[4\]d emonstrated the
PY - 1989/3
Y1 - 1989/3
N2 - The Trial of Antihypertensive Interventions and Management was a multicenter randomized, placebo-controlled trial designed to assess the effectiveness of various combinations of pharmacologic and dietary interventions in the treatment of mild hypertension (diastolic blood pressure 90-100 mmHg). The primary outcome was blood pressure change between baseline and 6 months. The study consisted of a 3 × 3 factorial design wherein participants were randomly allocated to nine drug-diet treatment groups. Drugs included placebo, diuretic, and beta-blocker. Diets were usual, weight loss, and low sodium/high potassium. The basic strategy was to address clinical questions of interest by comparing mean blood pressure changes of selected drug-diet combinations. This paper describes the study including experimental design, sample size considerations, statistical analysis, organizational structure, and baseline findings.
AB - The Trial of Antihypertensive Interventions and Management was a multicenter randomized, placebo-controlled trial designed to assess the effectiveness of various combinations of pharmacologic and dietary interventions in the treatment of mild hypertension (diastolic blood pressure 90-100 mmHg). The primary outcome was blood pressure change between baseline and 6 months. The study consisted of a 3 × 3 factorial design wherein participants were randomly allocated to nine drug-diet treatment groups. Drugs included placebo, diuretic, and beta-blocker. Diets were usual, weight loss, and low sodium/high potassium. The basic strategy was to address clinical questions of interest by comparing mean blood pressure changes of selected drug-diet combinations. This paper describes the study including experimental design, sample size considerations, statistical analysis, organizational structure, and baseline findings.
KW - Clinical trial design
KW - hypertension
KW - multiple comparisons
UR - http://www.scopus.com/inward/record.url?scp=0024581135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024581135&partnerID=8YFLogxK
U2 - 10.1016/0197-2456(89)90016-0
DO - 10.1016/0197-2456(89)90016-0
M3 - Article
C2 - 2649308
AN - SCOPUS:0024581135
SN - 0197-2456
VL - 10
SP - 11
EP - 30
JO - Controlled Clinical Trials
JF - Controlled Clinical Trials
IS - 1
ER -