Trial of antihypertensive interventions and management. Design, methods, and selected baseline results

Barry R. Davis, M. Donald Blaufox, C. Morton Hawkins, Herbert G. Langford, Albert Oberman, Charles Swencionis, Sylvia Wassertheil-Smoller, Judith Wylie-Rosett, Neal Zimbaldi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The Trial of Antihypertensive Interventions and Management was a multicenter randomized, placebo-controlled trial designed to assess the effectiveness of various combinations of pharmacologic and dietary interventions in the treatment of mild hypertension (diastolic blood pressure 90-100 mmHg). The primary outcome was blood pressure change between baseline and 6 months. The study consisted of a 3 × 3 factorial design wherein participants were randomly allocated to nine drug-diet treatment groups. Drugs included placebo, diuretic, and beta-blocker. Diets were usual, weight loss, and low sodium/high potassium. The basic strategy was to address clinical questions of interest by comparing mean blood pressure changes of selected drug-diet combinations. This paper describes the study including experimental design, sample size considerations, statistical analysis, organizational structure, and baseline findings.

Original languageEnglish (US)
Pages (from-to)11-30
Number of pages20
JournalControlled Clinical Trials
Volume10
Issue number1
DOIs
StatePublished - 1989

Fingerprint

Antihypertensive Agents
Blood Pressure
Diet
Placebos
Drug Combinations
Diuretics
Pharmaceutical Preparations
Sample Size
Weight Loss
Potassium
Research Design
Randomized Controlled Trials
Sodium
Hypertension
Therapeutics

Keywords

  • Clinical trial design
  • hypertension
  • multiple comparisons

ASJC Scopus subject areas

  • Pharmacology

Cite this

R. Davis, B., Blaufox, M. D., Hawkins, C. M., Langford, H. G., Oberman, A., Swencionis, C., ... Zimbaldi, N. (1989). Trial of antihypertensive interventions and management. Design, methods, and selected baseline results. Controlled Clinical Trials, 10(1), 11-30. https://doi.org/10.1016/0197-2456(89)90016-0

Trial of antihypertensive interventions and management. Design, methods, and selected baseline results. / R. Davis, Barry; Blaufox, M. Donald; Hawkins, C. Morton; Langford, Herbert G.; Oberman, Albert; Swencionis, Charles; Wassertheil-Smoller, Sylvia; Wylie-Rosett, Judith; Zimbaldi, Neal.

In: Controlled Clinical Trials, Vol. 10, No. 1, 1989, p. 11-30.

Research output: Contribution to journalArticle

R. Davis, B, Blaufox, MD, Hawkins, CM, Langford, HG, Oberman, A, Swencionis, C, Wassertheil-Smoller, S, Wylie-Rosett, J & Zimbaldi, N 1989, 'Trial of antihypertensive interventions and management. Design, methods, and selected baseline results', Controlled Clinical Trials, vol. 10, no. 1, pp. 11-30. https://doi.org/10.1016/0197-2456(89)90016-0
R. Davis, Barry ; Blaufox, M. Donald ; Hawkins, C. Morton ; Langford, Herbert G. ; Oberman, Albert ; Swencionis, Charles ; Wassertheil-Smoller, Sylvia ; Wylie-Rosett, Judith ; Zimbaldi, Neal. / Trial of antihypertensive interventions and management. Design, methods, and selected baseline results. In: Controlled Clinical Trials. 1989 ; Vol. 10, No. 1. pp. 11-30.
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