Trends in serum citrulline and acute rejection among recipients of small bowel transplants

P. A. Pappas, A. G. Tzakis, J. M. Saudubray, J. J. Gaynor, M. R. Carreno, F. Huijing, G. Kleiner, D. Rabier, T. Kato, D. M. Levi, S. Nishida, B. Gelman, John F. Thompson, N. Mittal, P. Ruiz

Research output: Contribution to journalArticle

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Abstract

A test for detecting acute cellular rejection (ACR) of small intestinal transplants (ITx) would be a major advance. Small preliminary studies suggest that serum citrulline levels correlate with ACR. The results for a group of 26 isolated intestinal and multivisceral transplant recipients are summarized here. Serum citrulline concentrations were determined by ion exchange chromatography and compared to biopsy-based grade of ACR. Other factors considered included patient and donor age and sex, ischemia time, and serum creatinine. Straight-line fits were employed to describe how each patient's citrulline levels changed over time. Estimated times to achieve normal citrulline (≥30 μmol/L) ranged from 1 to 730 days posttransplant for 21 patients demonstrating increasing citrulline levels over time. Using stepwise linear regression, patients' ranks for time required to achieve normal citrulline levels were the only independent predictors of both maximum ACR (P < .0001) and average ACR (P = .0059) after 14 days posttransplant. The rate and direction of change in citrulline over time may be an indicator of the risk of acute rejection. We plan to further examine the use of citrulline as a marker for rejection in larger prospective studies.

Original languageEnglish (US)
Pages (from-to)345-347
Number of pages3
JournalTransplantation Proceedings
Volume36
Issue number2
DOIs
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Citrulline
Transplants
Serum
Ion Exchange Chromatography
Linear Models
Creatinine
Ischemia
Tissue Donors
Prospective Studies
Biopsy

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Pappas, P. A., Tzakis, A. G., Saudubray, J. M., Gaynor, J. J., Carreno, M. R., Huijing, F., ... Ruiz, P. (2004). Trends in serum citrulline and acute rejection among recipients of small bowel transplants. Transplantation Proceedings, 36(2), 345-347. https://doi.org/10.1016/j.transproceed.2003.12.007

Trends in serum citrulline and acute rejection among recipients of small bowel transplants. / Pappas, P. A.; Tzakis, A. G.; Saudubray, J. M.; Gaynor, J. J.; Carreno, M. R.; Huijing, F.; Kleiner, G.; Rabier, D.; Kato, T.; Levi, D. M.; Nishida, S.; Gelman, B.; Thompson, John F.; Mittal, N.; Ruiz, P.

In: Transplantation Proceedings, Vol. 36, No. 2, 03.2004, p. 345-347.

Research output: Contribution to journalArticle

Pappas, PA, Tzakis, AG, Saudubray, JM, Gaynor, JJ, Carreno, MR, Huijing, F, Kleiner, G, Rabier, D, Kato, T, Levi, DM, Nishida, S, Gelman, B, Thompson, JF, Mittal, N & Ruiz, P 2004, 'Trends in serum citrulline and acute rejection among recipients of small bowel transplants', Transplantation Proceedings, vol. 36, no. 2, pp. 345-347. https://doi.org/10.1016/j.transproceed.2003.12.007
Pappas, P. A. ; Tzakis, A. G. ; Saudubray, J. M. ; Gaynor, J. J. ; Carreno, M. R. ; Huijing, F. ; Kleiner, G. ; Rabier, D. ; Kato, T. ; Levi, D. M. ; Nishida, S. ; Gelman, B. ; Thompson, John F. ; Mittal, N. ; Ruiz, P. / Trends in serum citrulline and acute rejection among recipients of small bowel transplants. In: Transplantation Proceedings. 2004 ; Vol. 36, No. 2. pp. 345-347.
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