Trends in gestational choriocarcinoma

A 27-year perspective

Harriet O. Smith, Clifford R. Qualls, Beth A. Prairie, Luis A. Padilla, William F. Rayburn, Charles R. Key

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate trends in incidence and survival rates for gestational choriocarcinoma with the use of population-based data. METHODS: Overall and 5-year average age-adjusted incidence rates were computed with the Surveillance, Epidemiology, and End Results program public-use database. Differences by age at diagnosis, race, stage, registry, and over calendar time were compared by Poisson regression, and survival censored for deaths other than choriocarcinoma by log-rank tests and Cox's proportional hazard ratios. RESULTS: Between 1973 and 1999, 450 cases were recorded. The annualized age-adjusted incidence rate for choriocarcinoma was 0.133 per 100,000 woman-years and decreased by 49.7% (2.8% per year). By race (whites, blacks, and others), incidence rates declined by 62.3%, 27.2%, and 54.3%, respectively. In the Poisson model evaluating incidence rates, age, race, registry, and stage were significant main effects. Compared with whites, the relative risk was higher for blacks (2.14, 95% confidence interval [CI] 1.60, 2.86) and others (2.30, 95% CI 1.67, 3.18). Rates were highest in Utah and lowest in Iowa. By age at diagnosis, rates were higher in 20-39-year-olds. The 5-year relative survival rate was 89.5%. Censored survival was significantly lower among blacks (whites 92.4%, blacks 84.9%, others 87.1%, P = .045), for advanced disease (localized 94.5%, regional 92.9%, distant 87.1%, P = .02), and with increasing age at diagnosis (P = .017). Age and calendar time significantly influenced censored survival independent of stage and registry. CONCLUSION: Gestational choriocarcinoma incidence rates have declined and survivals have improved, but blacks continue to have higher incidence and lower survival rates.

Original languageEnglish (US)
Pages (from-to)978-987
Number of pages10
JournalObstetrics and Gynecology
Volume102
Issue number5
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Choriocarcinoma
Incidence
Registries
Survival
Survival Rate
SEER Program
Confidence Intervals
Databases
Population

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Smith, H. O., Qualls, C. R., Prairie, B. A., Padilla, L. A., Rayburn, W. F., & Key, C. R. (2003). Trends in gestational choriocarcinoma: A 27-year perspective. Obstetrics and Gynecology, 102(5), 978-987. https://doi.org/10.1016/S0029-7844(03)00669-0

Trends in gestational choriocarcinoma : A 27-year perspective. / Smith, Harriet O.; Qualls, Clifford R.; Prairie, Beth A.; Padilla, Luis A.; Rayburn, William F.; Key, Charles R.

In: Obstetrics and Gynecology, Vol. 102, No. 5, 11.2003, p. 978-987.

Research output: Contribution to journalArticle

Smith, HO, Qualls, CR, Prairie, BA, Padilla, LA, Rayburn, WF & Key, CR 2003, 'Trends in gestational choriocarcinoma: A 27-year perspective', Obstetrics and Gynecology, vol. 102, no. 5, pp. 978-987. https://doi.org/10.1016/S0029-7844(03)00669-0
Smith, Harriet O. ; Qualls, Clifford R. ; Prairie, Beth A. ; Padilla, Luis A. ; Rayburn, William F. ; Key, Charles R. / Trends in gestational choriocarcinoma : A 27-year perspective. In: Obstetrics and Gynecology. 2003 ; Vol. 102, No. 5. pp. 978-987.
@article{bf36de21435848838489b9f9c814e6d3,
title = "Trends in gestational choriocarcinoma: A 27-year perspective",
abstract = "OBJECTIVE: To evaluate trends in incidence and survival rates for gestational choriocarcinoma with the use of population-based data. METHODS: Overall and 5-year average age-adjusted incidence rates were computed with the Surveillance, Epidemiology, and End Results program public-use database. Differences by age at diagnosis, race, stage, registry, and over calendar time were compared by Poisson regression, and survival censored for deaths other than choriocarcinoma by log-rank tests and Cox's proportional hazard ratios. RESULTS: Between 1973 and 1999, 450 cases were recorded. The annualized age-adjusted incidence rate for choriocarcinoma was 0.133 per 100,000 woman-years and decreased by 49.7{\%} (2.8{\%} per year). By race (whites, blacks, and others), incidence rates declined by 62.3{\%}, 27.2{\%}, and 54.3{\%}, respectively. In the Poisson model evaluating incidence rates, age, race, registry, and stage were significant main effects. Compared with whites, the relative risk was higher for blacks (2.14, 95{\%} confidence interval [CI] 1.60, 2.86) and others (2.30, 95{\%} CI 1.67, 3.18). Rates were highest in Utah and lowest in Iowa. By age at diagnosis, rates were higher in 20-39-year-olds. The 5-year relative survival rate was 89.5{\%}. Censored survival was significantly lower among blacks (whites 92.4{\%}, blacks 84.9{\%}, others 87.1{\%}, P = .045), for advanced disease (localized 94.5{\%}, regional 92.9{\%}, distant 87.1{\%}, P = .02), and with increasing age at diagnosis (P = .017). Age and calendar time significantly influenced censored survival independent of stage and registry. CONCLUSION: Gestational choriocarcinoma incidence rates have declined and survivals have improved, but blacks continue to have higher incidence and lower survival rates.",
author = "Smith, {Harriet O.} and Qualls, {Clifford R.} and Prairie, {Beth A.} and Padilla, {Luis A.} and Rayburn, {William F.} and Key, {Charles R.}",
year = "2003",
month = "11",
doi = "10.1016/S0029-7844(03)00669-0",
language = "English (US)",
volume = "102",
pages = "978--987",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Trends in gestational choriocarcinoma

T2 - A 27-year perspective

AU - Smith, Harriet O.

AU - Qualls, Clifford R.

AU - Prairie, Beth A.

AU - Padilla, Luis A.

AU - Rayburn, William F.

AU - Key, Charles R.

PY - 2003/11

Y1 - 2003/11

N2 - OBJECTIVE: To evaluate trends in incidence and survival rates for gestational choriocarcinoma with the use of population-based data. METHODS: Overall and 5-year average age-adjusted incidence rates were computed with the Surveillance, Epidemiology, and End Results program public-use database. Differences by age at diagnosis, race, stage, registry, and over calendar time were compared by Poisson regression, and survival censored for deaths other than choriocarcinoma by log-rank tests and Cox's proportional hazard ratios. RESULTS: Between 1973 and 1999, 450 cases were recorded. The annualized age-adjusted incidence rate for choriocarcinoma was 0.133 per 100,000 woman-years and decreased by 49.7% (2.8% per year). By race (whites, blacks, and others), incidence rates declined by 62.3%, 27.2%, and 54.3%, respectively. In the Poisson model evaluating incidence rates, age, race, registry, and stage were significant main effects. Compared with whites, the relative risk was higher for blacks (2.14, 95% confidence interval [CI] 1.60, 2.86) and others (2.30, 95% CI 1.67, 3.18). Rates were highest in Utah and lowest in Iowa. By age at diagnosis, rates were higher in 20-39-year-olds. The 5-year relative survival rate was 89.5%. Censored survival was significantly lower among blacks (whites 92.4%, blacks 84.9%, others 87.1%, P = .045), for advanced disease (localized 94.5%, regional 92.9%, distant 87.1%, P = .02), and with increasing age at diagnosis (P = .017). Age and calendar time significantly influenced censored survival independent of stage and registry. CONCLUSION: Gestational choriocarcinoma incidence rates have declined and survivals have improved, but blacks continue to have higher incidence and lower survival rates.

AB - OBJECTIVE: To evaluate trends in incidence and survival rates for gestational choriocarcinoma with the use of population-based data. METHODS: Overall and 5-year average age-adjusted incidence rates were computed with the Surveillance, Epidemiology, and End Results program public-use database. Differences by age at diagnosis, race, stage, registry, and over calendar time were compared by Poisson regression, and survival censored for deaths other than choriocarcinoma by log-rank tests and Cox's proportional hazard ratios. RESULTS: Between 1973 and 1999, 450 cases were recorded. The annualized age-adjusted incidence rate for choriocarcinoma was 0.133 per 100,000 woman-years and decreased by 49.7% (2.8% per year). By race (whites, blacks, and others), incidence rates declined by 62.3%, 27.2%, and 54.3%, respectively. In the Poisson model evaluating incidence rates, age, race, registry, and stage were significant main effects. Compared with whites, the relative risk was higher for blacks (2.14, 95% confidence interval [CI] 1.60, 2.86) and others (2.30, 95% CI 1.67, 3.18). Rates were highest in Utah and lowest in Iowa. By age at diagnosis, rates were higher in 20-39-year-olds. The 5-year relative survival rate was 89.5%. Censored survival was significantly lower among blacks (whites 92.4%, blacks 84.9%, others 87.1%, P = .045), for advanced disease (localized 94.5%, regional 92.9%, distant 87.1%, P = .02), and with increasing age at diagnosis (P = .017). Age and calendar time significantly influenced censored survival independent of stage and registry. CONCLUSION: Gestational choriocarcinoma incidence rates have declined and survivals have improved, but blacks continue to have higher incidence and lower survival rates.

UR - http://www.scopus.com/inward/record.url?scp=0242543056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242543056&partnerID=8YFLogxK

U2 - 10.1016/S0029-7844(03)00669-0

DO - 10.1016/S0029-7844(03)00669-0

M3 - Article

VL - 102

SP - 978

EP - 987

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 5

ER -