TY - JOUR
T1 - Treatment with buprenorphine prior to EcoHIV infection of mice prevents the development of neurocognitive impairment
AU - Jaureguiberry-Bravo, Matias
AU - Kelschenbach, Jennifer
AU - Murphy, Aniella
AU - Carvallo, Loreto
AU - Hadas, Eran
AU - Tesfa, Lydia
AU - Scott, Travis M.
AU - Rivera-Mindt, Monica
AU - Cunningham, Chinazo O.
AU - Arnsten, Julia H.
AU - Volsky, David J.
AU - Berman, Joan W.
N1 - Publisher Copyright:
© 2020 Society for Leukocyte Biology
PY - 2021/3
Y1 - 2021/3
N2 - Approximately 15–40% of people living with HIV develop HIV-associated neurocognitive disorders, HAND, despite successful antiretroviral therapy. There are no therapies to treat these disorders. HIV enters the CNS early after infection, in part by transmigration of infected monocytes. Currently, there is a major opioid epidemic in the United States. Opioid use disorder in the context of HIV infection is important because studies show that opioids exacerbate HIV-mediated neuroinflammation that may contribute to more severe cognitive deficits. Buprenorphine is an opioid derivate commonly prescribed for opiate agonist treatment. We used the EcoHIV mouse model to study the effects of buprenorphine on cognitive impairment and to correlate these with monocyte migration into the CNS. We show that buprenorphine treatment prior to mouse EcoHIV infection prevents the development of cognitive impairment, in part, by decreased accumulation of monocytes in the brain. We propose that buprenorphine has a novel therapeutic benefit of limiting the development of neurocognitive impairment in HIV-infected opioid abusers as well as in nonabusers, in addition to decreasing the use of harmful opioids. Buprenorphine may also be used in combination with HIV prevention strategies such as pre-exposure prophylaxis because of its safety profile.
AB - Approximately 15–40% of people living with HIV develop HIV-associated neurocognitive disorders, HAND, despite successful antiretroviral therapy. There are no therapies to treat these disorders. HIV enters the CNS early after infection, in part by transmigration of infected monocytes. Currently, there is a major opioid epidemic in the United States. Opioid use disorder in the context of HIV infection is important because studies show that opioids exacerbate HIV-mediated neuroinflammation that may contribute to more severe cognitive deficits. Buprenorphine is an opioid derivate commonly prescribed for opiate agonist treatment. We used the EcoHIV mouse model to study the effects of buprenorphine on cognitive impairment and to correlate these with monocyte migration into the CNS. We show that buprenorphine treatment prior to mouse EcoHIV infection prevents the development of cognitive impairment, in part, by decreased accumulation of monocytes in the brain. We propose that buprenorphine has a novel therapeutic benefit of limiting the development of neurocognitive impairment in HIV-infected opioid abusers as well as in nonabusers, in addition to decreasing the use of harmful opioids. Buprenorphine may also be used in combination with HIV prevention strategies such as pre-exposure prophylaxis because of its safety profile.
KW - inflammation
KW - monocytes
KW - neuroAIDS
KW - opioids
KW - water maze
UR - http://www.scopus.com/inward/record.url?scp=85087176197&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85087176197&partnerID=8YFLogxK
U2 - 10.1002/JLB.5AB0420-531R
DO - 10.1002/JLB.5AB0420-531R
M3 - Article
C2 - 32578908
AN - SCOPUS:85087176197
SN - 0741-5400
VL - 109
SP - 675
EP - 681
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 3
ER -