Treatment-related changes in serum lipids and inflammation: Clinical relevance remains unclear. Analyses from the Women's Interagency HIV study

Christina M. Parrinello, Alan L. Landay, Howard N. Hodis, Stephen J. Gange, Philip J. Norris, Mary Young, Kathryn Anastos, Phyllis C. Tien, Xiaonan Xue, Jason Lazar, Lorie Benning, Russell P. Tracy, Robert C. Kaplan

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Among 127 HIV-infected women, the magnitude of high-density lipoprotein cholesterol (HDLc) increases after HAART initiation predicted the magnitude of concurrent decreases in inflammation biomarkers. After HAART initiation, changes in low-density lipoprotein cholesterol (LDLc) and inflammation were unrelated. In the same population, predicted risk of coronary heart disease, based upon levels of standard clinical risk factors, was similar before and after HAART. Thus, it remains unknown whether short-term treatment-related changes in standard risk factors may appreciably change risk of cardiovascular disease (CVD).

Original languageEnglish (US)
Pages (from-to)1516-1519
Number of pages4
JournalAIDS
Volume27
Issue number9
DOIs
StatePublished - Jun 1 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Parrinello, C. M., Landay, A. L., Hodis, H. N., Gange, S. J., Norris, P. J., Young, M., Anastos, K., Tien, P. C., Xue, X., Lazar, J., Benning, L., Tracy, R. P., & Kaplan, R. C. (2013). Treatment-related changes in serum lipids and inflammation: Clinical relevance remains unclear. Analyses from the Women's Interagency HIV study. AIDS, 27(9), 1516-1519. https://doi.org/10.1097/QAD.0b013e32835fd8a9