Treatment of Vitamin D Deficiency in Predominantly Hispanic and Black Adolescents: A Randomized Clinical Trial

Hina J. Talib, Tulasi Ponnapakkam, Robert Gensure, Hillel W. Cohen, Susan M. Coupey

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6 Scopus citations

Abstract

Objectives To compare 3 different treatment regimens for Vitamin D deficiency in minority adolescents and to explore factors that impact treatment efficacy. Study design We conducted an 8-week, prospective, open-label, randomized clinical trial in an urban, academic, children's hospital. A total of 183 Vitamin D-deficient adolescents, mean 25-hydroxyVitamin D or 25(OH)D 13.7 ± 3.9 ng/mL; mean age 16.6 ± 2.2 years, were randomized into 3 Vitamin D3 (cholecalciferol) treatment arms: 50 000 IU/wk; 5000 IU/d; and 1000 IU/d. Serum 25(OH)D and Vitamin D binding protein (VDBP) levels were measured pre-and posttreatment; 122 (67%) participants completed posttreatment measures. Complete-case and multiple-imputation, intention-to-treat analyses were performed. Results Mean change in 25(OH)D level posttreatment was significantly different among the 3 arms, 24.9 ± 15.1 vs 21.0 ± 15.2 vs 6.2 ± 6.5 ng/mL, for 50 000 IU, 5000 IU, and 1000 IU doses, respectively, P 30 ng/mL) with 50 000 IU, 5000 IU, and 1000 IU doses, respectively, P

Original languageEnglish (US)
Pages (from-to)266-272e1
JournalJournal of Pediatrics
Volume170
DOIs
StatePublished - Mar 1 2016

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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