Treatment of Rabbit Liver Cancer In Vivo Using Miniaturized Image-Ablate Ultrasound Arrays

T. Douglas Mast, Peter G. Barthe, Inder Raj S. Makin, Michael H. Slayton, Chandra Priya Karunakaran, Mark T. Burgess, Amel Alqadah, Steven M. Rudich

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In the preclinical studies reported here, VX2 cancer within rabbit liver has been treated by bulk ultrasound ablation employing miniaturized image-ablate arrays. Array probes were constructed with 32 elements in a 2.3 × 20 mm 2 aperture, packaged within a 3.1 mm stainless steel tube with a cooling and coupling balloon for in vivo use. The probes were measured capable of 50% fractional bandwidth for pulse-echo imaging (center frequency 4.4 MHz) with >110 W/cm 2 surface intensity available at sonication frequencies 3.5 and 4.8 MHz. B-scan imaging performance of the arrays was measured to be comparable to larger diagnostic linear arrays, although nearfield image quality was reduced by ringdown artifacts. A series of in vivo ablation procedures was performed using an unfocused 32-element aperture firing at 4.8 MHz with exposure durations 20-70.5 s and in situ spatial average, temporal average intensities 22.4-38.5 W/cm 2. Ablation of a complete tumor cross-section was confirmed by vital staining in seven of 12 exposures, with four exposures ablating an additional margin >1 mm beyond the tumor in all directions. Analysis suggests a threshold ablation effect, with complete ablation of tumor cross-sections for exposures with delivery of >838 J acoustic energy. The results show feasibility for in vivo liver cancer ablation using miniaturized image-ablate arrays suitable for interstitial deployment.

Original languageEnglish (US)
Pages (from-to)1609-1621
Number of pages13
JournalUltrasound in Medicine and Biology
Volume37
Issue number10
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

Fingerprint

rabbits
Liver Neoplasms
liver
ablation
cancer
Rabbits
Neoplasms
tumors
Sonication
Stainless Steel
apertures
Acoustics
Artifacts
probes
cross sections
linear arrays
staining
balloons
Staining and Labeling
artifacts

Keywords

  • Arrays
  • Image guidance
  • Liver cancer
  • Therapeutic ultrasound
  • Thermal ablation
  • VX2 rabbit tumor

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

Cite this

Treatment of Rabbit Liver Cancer In Vivo Using Miniaturized Image-Ablate Ultrasound Arrays. / Mast, T. Douglas; Barthe, Peter G.; Makin, Inder Raj S.; Slayton, Michael H.; Karunakaran, Chandra Priya; Burgess, Mark T.; Alqadah, Amel; Rudich, Steven M.

In: Ultrasound in Medicine and Biology, Vol. 37, No. 10, 01.10.2011, p. 1609-1621.

Research output: Contribution to journalArticle

Mast, TD, Barthe, PG, Makin, IRS, Slayton, MH, Karunakaran, CP, Burgess, MT, Alqadah, A & Rudich, SM 2011, 'Treatment of Rabbit Liver Cancer In Vivo Using Miniaturized Image-Ablate Ultrasound Arrays', Ultrasound in Medicine and Biology, vol. 37, no. 10, pp. 1609-1621. https://doi.org/10.1016/j.ultrasmedbio.2011.05.850
Mast, T. Douglas ; Barthe, Peter G. ; Makin, Inder Raj S. ; Slayton, Michael H. ; Karunakaran, Chandra Priya ; Burgess, Mark T. ; Alqadah, Amel ; Rudich, Steven M. / Treatment of Rabbit Liver Cancer In Vivo Using Miniaturized Image-Ablate Ultrasound Arrays. In: Ultrasound in Medicine and Biology. 2011 ; Vol. 37, No. 10. pp. 1609-1621.
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