Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone

Shaun A. Hussain, Shlomo Shinnar, Grace Kwong, Jason T. Lerner, Joyce H. Matsumoto, Joyce Y. Wu, W. Donald Shields, Raman Sankar

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Purpose This study investigated the short-term response to a standardized hormonal therapy protocol for treatment of infantile spasms. Methods Twenty-seven children with video electroencephalography (EEG)-confirmed infantile spasms received very high dose (8 mg/kg/day, max 60 mg/day) oral prednisolone for 2 weeks. Response (absence of both hypsarrhythmia and spasms) to prednisolone was ascertained by repeat overnight video-EEG. Responders were tapered over 2 weeks and nonresponders were immediately transitioned to high dose (150 IU/m2/day) intramuscular adrenocorticotropic hormone (ACTH) for two additional weeks. Response was again determined by overnight video-EEG after ACTH therapy. Key Findings Sixty-three percent (17/27) of patients responded completely to prednisolone. Subsequently, 40% (4/10) of prednisolone nonresponders exhibited a complete response after an additional 2-week course with ACTH. Among 27 subjects with median follow-up of 13.5 months (interquartile range [IQR] 4.8-25.9), 12% (2/17) of prednisolone responders and 50% (2/4) of ACTH responders experienced a relapse between 2 and 9 months after initial response. Significance Very high dose prednisolone demonstrated significantly higher efficacy than previously reported for lower doses in prior studies. High dose ACTH may be superior to very high dose prednisolone, and in lieu of a definitive clinical trial, the choice between prednisolone and ACTH for initial treatment of infantile spasms remains controversial.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalEpilepsia
Volume55
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Infantile Spasms
Prednisolone
Adrenocorticotropic Hormone
Electroencephalography
Therapeutics
Spasm
Clinical Protocols
Clinical Trials
Recurrence

Keywords

  • ACTHar
  • Corticosteroids
  • Corticotropin
  • Hypsarrhythmia
  • West syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Hussain, S. A., Shinnar, S., Kwong, G., Lerner, J. T., Matsumoto, J. H., Wu, J. Y., ... Sankar, R. (2014). Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone. Epilepsia, 55(1), 103-107. https://doi.org/10.1111/epi.12460

Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone. / Hussain, Shaun A.; Shinnar, Shlomo; Kwong, Grace; Lerner, Jason T.; Matsumoto, Joyce H.; Wu, Joyce Y.; Shields, W. Donald; Sankar, Raman.

In: Epilepsia, Vol. 55, No. 1, 01.2014, p. 103-107.

Research output: Contribution to journalArticle

Hussain, SA, Shinnar, S, Kwong, G, Lerner, JT, Matsumoto, JH, Wu, JY, Shields, WD & Sankar, R 2014, 'Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone', Epilepsia, vol. 55, no. 1, pp. 103-107. https://doi.org/10.1111/epi.12460
Hussain, Shaun A. ; Shinnar, Shlomo ; Kwong, Grace ; Lerner, Jason T. ; Matsumoto, Joyce H. ; Wu, Joyce Y. ; Shields, W. Donald ; Sankar, Raman. / Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone. In: Epilepsia. 2014 ; Vol. 55, No. 1. pp. 103-107.
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AB - Purpose This study investigated the short-term response to a standardized hormonal therapy protocol for treatment of infantile spasms. Methods Twenty-seven children with video electroencephalography (EEG)-confirmed infantile spasms received very high dose (8 mg/kg/day, max 60 mg/day) oral prednisolone for 2 weeks. Response (absence of both hypsarrhythmia and spasms) to prednisolone was ascertained by repeat overnight video-EEG. Responders were tapered over 2 weeks and nonresponders were immediately transitioned to high dose (150 IU/m2/day) intramuscular adrenocorticotropic hormone (ACTH) for two additional weeks. Response was again determined by overnight video-EEG after ACTH therapy. Key Findings Sixty-three percent (17/27) of patients responded completely to prednisolone. Subsequently, 40% (4/10) of prednisolone nonresponders exhibited a complete response after an additional 2-week course with ACTH. Among 27 subjects with median follow-up of 13.5 months (interquartile range [IQR] 4.8-25.9), 12% (2/17) of prednisolone responders and 50% (2/4) of ACTH responders experienced a relapse between 2 and 9 months after initial response. Significance Very high dose prednisolone demonstrated significantly higher efficacy than previously reported for lower doses in prior studies. High dose ACTH may be superior to very high dose prednisolone, and in lieu of a definitive clinical trial, the choice between prednisolone and ACTH for initial treatment of infantile spasms remains controversial.

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