Treatment of AIDS-related lymphomas

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Infection with HIV is associated with an increased risk of systemic and primary central nervous system non-Hodgkin's lymphoma. Patients with systemic non-Hodgkin's lymphoma usually present with high- or intermediate-grade histology and extranodal dissemination. Although the prognosis for such patients is poor, some patients clearly benefit from combination chemotherapy, and several new treatment approaches appear promising. Primary central nervous system lymphoma usually occurs in patients with more profound immunosuppression and is associated with a dismal prognosis. Selected patients with good performance status may benefit from therapy, particularly if opportunistic infections have been few and nondebilitating. Finally, Hodgkin's disease has been reported in patients with HIV infection, particularly in patients with a history of intravenous drug use, and it is more likely to present with advanced-stage disease and unfavorable histology.

Original languageEnglish (US)
Pages (from-to)442-449
Number of pages8
JournalCurrent Opinion in Oncology
Volume7
Issue number5
StatePublished - 1995

Fingerprint

AIDS-Related Lymphoma
Non-Hodgkin's Lymphoma
Therapeutics
HIV Infections
Histology
Central Nervous System
Opportunistic Infections
Combination Drug Therapy
Hodgkin Disease
Immunosuppression
Lymphoma

ASJC Scopus subject areas

  • Cancer Research

Cite this

Treatment of AIDS-related lymphomas. / Sparano, Joseph A.

In: Current Opinion in Oncology, Vol. 7, No. 5, 1995, p. 442-449.

Research output: Contribution to journalArticle

@article{c6694dbb7a6940bbb9d5902d37dbe11a,
title = "Treatment of AIDS-related lymphomas",
abstract = "Infection with HIV is associated with an increased risk of systemic and primary central nervous system non-Hodgkin's lymphoma. Patients with systemic non-Hodgkin's lymphoma usually present with high- or intermediate-grade histology and extranodal dissemination. Although the prognosis for such patients is poor, some patients clearly benefit from combination chemotherapy, and several new treatment approaches appear promising. Primary central nervous system lymphoma usually occurs in patients with more profound immunosuppression and is associated with a dismal prognosis. Selected patients with good performance status may benefit from therapy, particularly if opportunistic infections have been few and nondebilitating. Finally, Hodgkin's disease has been reported in patients with HIV infection, particularly in patients with a history of intravenous drug use, and it is more likely to present with advanced-stage disease and unfavorable histology.",
author = "Sparano, {Joseph A.}",
year = "1995",
language = "English (US)",
volume = "7",
pages = "442--449",
journal = "Current Opinion in Oncology",
issn = "1040-8746",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Treatment of AIDS-related lymphomas

AU - Sparano, Joseph A.

PY - 1995

Y1 - 1995

N2 - Infection with HIV is associated with an increased risk of systemic and primary central nervous system non-Hodgkin's lymphoma. Patients with systemic non-Hodgkin's lymphoma usually present with high- or intermediate-grade histology and extranodal dissemination. Although the prognosis for such patients is poor, some patients clearly benefit from combination chemotherapy, and several new treatment approaches appear promising. Primary central nervous system lymphoma usually occurs in patients with more profound immunosuppression and is associated with a dismal prognosis. Selected patients with good performance status may benefit from therapy, particularly if opportunistic infections have been few and nondebilitating. Finally, Hodgkin's disease has been reported in patients with HIV infection, particularly in patients with a history of intravenous drug use, and it is more likely to present with advanced-stage disease and unfavorable histology.

AB - Infection with HIV is associated with an increased risk of systemic and primary central nervous system non-Hodgkin's lymphoma. Patients with systemic non-Hodgkin's lymphoma usually present with high- or intermediate-grade histology and extranodal dissemination. Although the prognosis for such patients is poor, some patients clearly benefit from combination chemotherapy, and several new treatment approaches appear promising. Primary central nervous system lymphoma usually occurs in patients with more profound immunosuppression and is associated with a dismal prognosis. Selected patients with good performance status may benefit from therapy, particularly if opportunistic infections have been few and nondebilitating. Finally, Hodgkin's disease has been reported in patients with HIV infection, particularly in patients with a history of intravenous drug use, and it is more likely to present with advanced-stage disease and unfavorable histology.

UR - http://www.scopus.com/inward/record.url?scp=0029146848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029146848&partnerID=8YFLogxK

M3 - Article

C2 - 8541390

AN - SCOPUS:0029146848

VL - 7

SP - 442

EP - 449

JO - Current Opinion in Oncology

JF - Current Opinion in Oncology

SN - 1040-8746

IS - 5

ER -