Treating clostridium difficile infection with fecal microbiota transplantation

Johan S. Bakken, Thomas Borody, Lawrence J. Brandt, Joel V. Brill, Daniel C. Demarco, Marc Alaric Franzos, Colleen Kelly, Alexander Khoruts, Thomas Louie, Lawrence P. Martinelli, Thomas A. Moore, George Russell, Christina Surawicz

Research output: Contribution to journalArticle

531 Scopus citations

Abstract

Clostridium difficile infection is increasing in incidence, severity, and mortality. Treatment options are limited and appear to be losing efficacy. Recurrent disease is especially challenging; extended treatment with oral vancomycin is becoming increasingly common but is expensive. Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured. We discuss the rationale, methods, and use of fecal microbiota transplantation.

Original languageEnglish (US)
Pages (from-to)1044-1049
Number of pages6
JournalClinical Gastroenterology and Hepatology
Volume9
Issue number12
DOIs
StatePublished - Dec 1 2011

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Keywords

  • Clostridium difficile
  • Diarrhea
  • Fecal Enema
  • Microbiota
  • Recurrent Infection
  • Transplantation

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Bakken, J. S., Borody, T., Brandt, L. J., Brill, J. V., Demarco, D. C., Franzos, M. A., Kelly, C., Khoruts, A., Louie, T., Martinelli, L. P., Moore, T. A., Russell, G., & Surawicz, C. (2011). Treating clostridium difficile infection with fecal microbiota transplantation. Clinical Gastroenterology and Hepatology, 9(12), 1044-1049. https://doi.org/10.1016/j.cgh.2011.08.014