Abstract
Activation of oncoproteins and inactivation of tumor suppressors induces tumorigenesis. When these events happen upstream of pRb and p53, cancer therapies may initially succeed and then fail when pRb and p53 are activated and then re-inactivated. Therapies might succeed if they remain effective when pRb and p53 are genetically inactivated.
Original language | English (US) |
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Article number | e1004954 |
Journal | Molecular and Cellular Oncology |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2 2015 |
Externally published | Yes |
Keywords
- Skp2
- cancer therapy
- genetic inactivation
- miR-17-92
- p53
- pRb
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research