@article{63e0be58ec994df2820a26c8b610ecf2,
title = "Treadmill-based task for assessing spatial memory in head-fixed mice",
abstract = "Several mouse in vivo neuronal recording techniques require head fixation. Head-fixed treadmill walking can be used to design tasks that enable the study of neural activity in the context of behavior. Here, we provide a detailed protocol for constructing a treadmill with tactile spatial cues, training mice on a rewarded behavioral task, and analyzing behavioral data. We discuss common problems and solutions we have developed to optimize training. Finally, we demonstrate how to test spatial memory performance using this task.",
keywords = "Behavior, Microscopy, Model Organisms, Neuroscience",
author = "Jordan, {Jake T.} and McDermott, {Kelsey D.} and Frechou, {M. Agustina} and Matthew Shtrahman and Gon{\c c}alves, {J. Tiago}",
note = "Funding Information: J.T.J. was funded by an NIH T32 training grant (5 T32 HD098067-03 ) and would like to thank the Intellectual and Developmental Disabilities Research Center for its support ( 1 P50 HD105352-01 ; support for the Rose F. Kennedy IDDRC). K.D.M. and M.A.F. were funded by The Einstein Training Program in Stem Cell Research from the Empire State Stem Cell Fund through New York State Department of Health Contract C34874GG . M.S. was funded by a NINDS K08 grant ( NS093130 ) and a NIBIB R21 Trailblazer Award ( EB029139-01 ). Whitehall Foundation Research Grant ( 2019-05-71 ) was provided to J.T.G. We would like to thank Ehsan Sabri, Eliezyer Fermino De Oliveira, Luke Sjulson, and Renata Batista-Brito for technical advice and assistance. Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = sep,
day = "17",
doi = "10.1016/j.xpro.2021.100770",
language = "English (US)",
volume = "2",
journal = "STAR Protocols",
issn = "2666-1667",
publisher = "Cell Press",
number = "3",
}