Transplanted isolated hepatocytes: Effect of partial hepatectomy on proliferation of long-term syngeneic implants in rat spleen

Sanjeev Gupta, Robin Johnstone, Helen Darby, Clare Selden, Yvonne Price, Humphrey J. Hodgson

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Proliferation of isolated hepatocytes in long-term splenic implants was assessed by flash labelling with a 1 pulse of tritiated thymidine (3H TdR). Cell kinetics showed that the basal labelling index was 0.9% which was greater than normal non-regenerating liver. Twenty four hours following partial hepatectomy the labelling index was 2.0%, a significant rise. These results suggest that hepatocytes transplanted to the spleen constitute a suitable model for screening putative hepatotrophic factors, and are of relevance in establishing clinically useful models of hepatocyte transplantation.

Original languageEnglish (US)
Pages (from-to)28-30
Number of pages3
JournalPathology
Volume19
Issue number1
DOIs
StatePublished - Jan 1987
Externally publishedYes

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Keywords

  • Cell proliferation
  • Hepatocellular transplantation
  • Partial hepatectomy
  • Rat spleen

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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