Abstract
Proliferation of isolated hepatocytes in long-term splenic implants was assessed by flash labelling with a 1 pulse of tritiated thymidine (3H TdR). Cell kinetics showed that the basal labelling index was 0.9% which was greater than normal non-regenerating liver. Twenty four hours following partial hepatectomy the labelling index was 2.0%, a significant rise. These results suggest that hepatocytes transplanted to the spleen constitute a suitable model for screening putative hepatotrophic factors, and are of relevance in establishing clinically useful models of hepatocyte transplantation.
Original language | English (US) |
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Pages (from-to) | 28-30 |
Number of pages | 3 |
Journal | Pathology |
Volume | 19 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1987 |
Externally published | Yes |
Keywords
- Cell proliferation
- Hepatocellular transplantation
- Partial hepatectomy
- Rat spleen
ASJC Scopus subject areas
- Pathology and Forensic Medicine