The authors created transmesothelial ultrafiltration in vitro by inducing an osmotic gradient (vasc-300 mOsm: meso-400 mOsm) across the membrane. Calculated value of hydraulic conductivity of the mesothelium is comparable with analogous value for endothelium of the microvessels. They propose that transperitoneal ultrafiltration develops in two phases: Transmesothelial ultrafiltration, which augments tonicity of the interstitial tissue which is followed by transendothelial ultrafiltration due to the osmotic gradient between the dehydrated interstitium and the vascular space. Hypertonic medium on the mesothelial side of the membrane modified its permeability to various solutes: transport rate of urea and inulin was increased whereas transport rate of albumin decreased.
|Original language||English (US)|
|Number of pages||4|
|Journal||Peritoneal Dialysis Bulletin|
|Publication status||Published - Jan 1 1986|
ASJC Scopus subject areas